Association of Urological Symptoms and Chronic Illness in Men and Women: Contributions of Symptom Severity and Duration--results from the BACH Survey

Overview

Journal J Urol

Publisher Wolters Kluwer

Specialty Urology

Date 2008 Dec 19

PMID 19091335

Citations 40

Authors

Varant Kupelian

Raymond C Rosen

Carol L Link

Kevin T McVary

Lalitha Padmanabhan Aiyer

Patrick Mollon

Steven A Kaplan

John B McKinlay

Affiliations

Soon will be listed here.

Abstract

Purpose: We investigated the association between lower urinary tract symptoms and chronic illness, such as heart disease, diabetes, hypertension and depression, in men and women. In addition, we determined whether a dose-response relationship exists in the association between the severity and duration of urological symptoms and major chronic illnesses.

Materials And Methods: The Boston Area Community Health Survey used a multistage stratified design to recruit a random sample of 5,503 adults who were 30 to 79 years old. Urological symptoms in the American Urological Association symptom index were included in analysis.

Results: Statistically significant associations that were consistent by gender were observed between depression and all urological symptoms. Nocturia of any degree of severity or duration was associated with heart disease in men and with diabetes in women. In men a dose-response relationship was observed for the association of symptom severity and/or the duration of urinary intermittency and frequency with heart disease, and for the association of urinary urgency with diabetes. In women a history of heart disease was associated with a weak stream and straining, while a history of hypertension was associated with urgency and a weak stream.

Conclusions: Results indicate a dose-response relationship in the association of the severity and duration of urological symptoms with major chronic illnesses. An association between urinary symptoms and depression was observed in men and women. In contrast, the association between lower urinary tract symptoms and heart disease, diabetes or hypertension varied by gender, suggesting different mechanisms of association in men and women.

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References

Badia X, Garcia-Losa M, Dal-Re R, Carballido J, Serra M . Validation of a harmonized Spanish version of the IPSS: evidence of equivalence with the original American scale. International Prostate Symptom Score. Urology. 1998; 52(4):614-20. DOI: 10.1016/s0090-4295(98)00204-0. View

Boyle P, Robertson C, Mazzetta C, KEECH M, Hobbs F, Fourcade R . The prevalence of lower urinary tract symptoms in men and women in four centres. The UrEpik study. BJU Int. 2003; 92(4):409-14. DOI: 10.1046/j.1464-410x.2003.04369.x. View

Okura Y, Urban L, Mahoney D, Jacobsen S, Rodeheffer R . Agreement between self-report questionnaires and medical record data was substantial for diabetes, hypertension, myocardial infarction and stroke but not for heart failure. J Clin Epidemiol. 2004; 57(10):1096-103. DOI: 10.1016/j.jclinepi.2004.04.005. View

Haab F . Discussion: nitric oxide and bladder overactivity. Urology. 2000; 55(5A Suppl):58-9. DOI: 10.1016/s0090-4295(99)00496-3. View

Welch G, Weinger K, Barry M . Quality-of-life impact of lower urinary tract symptom severity: results from the Health Professionals Follow-up Study. Urology. 2002; 59(2):245-50. DOI: 10.1016/s0090-4295(01)01506-0. View

Finkelstein M . Medical conditions, medications, and urinary incontinence. Analysis of a population-based survey. Can Fam Physician. 2002; 48:96-101. PMC: 2213925. View

Fitzgerald M, Link C, Litman H, Travison T, McKinlay J . Beyond the lower urinary tract: the association of urologic and sexual symptoms with common illnesses. Eur Urol. 2007; 52(2):407-15. PMC: 2396456. DOI: 10.1016/j.eururo.2007.03.014. View

Green L . Manual for scoring socioeconomic status for research on health behavior. Public Health Rep (1896). 1970; 85(9):815-27. PMC: 2031767. View

Rohrmann S, Smit E, Giovannucci E, Platz E . Association between markers of the metabolic syndrome and lower urinary tract symptoms in the Third National Health and Nutrition Examination Survey (NHANES III). Int J Obes (Lond). 2005; 29(3):310-6. DOI: 10.1038/sj.ijo.0802881. View

10.

Burke J, Jacobson D, McGree M, Roberts R, Girman C, Lieber M . Diabetes and benign prostatic hyperplasia progression in Olmsted County, Minnesota. Urology. 2006; 67(1):22-5. DOI: 10.1016/j.urology.2005.08.010. View

11.

Rohrmann S, Crespo C, Weber J, Smit E, Giovannucci E, Platz E . Association of cigarette smoking, alcohol consumption and physical activity with lower urinary tract symptoms in older American men: findings from the third National Health And Nutrition Examination Survey. BJU Int. 2005; 96(1):77-82. DOI: 10.1111/j.1464-410X.2005.05571.x. View

12.

Joseph M, Harlow S, Wei J, Sarma A, Dunn R, Taylor J . Risk factors for lower urinary tract symptoms in a population-based sample of African-American men. Am J Epidemiol. 2003; 157(10):906-14. DOI: 10.1093/aje/kwg051. View

13.

Turvey C, Wallace R, Herzog R . A revised CES-D measure of depressive symptoms and a DSM-based measure of major depressive episodes in the elderly. Int Psychogeriatr. 2001; 11(2):139-48. DOI: 10.1017/s1041610299005694. View

14.

Almeida R, Felisbino C, Lopez M, Rodrigues A, Gabilan N . Evidence for the involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of memantine in mice. Behav Brain Res. 2006; 168(2):318-22. DOI: 10.1016/j.bbr.2005.11.023. View

15.

Fitzgerald M, Mueller E . Physiology of the lower urinary tract. Clin Obstet Gynecol. 2004; 47(1):18-27. DOI: 10.1097/00003081-200403000-00005. View

16.

McKinlay J, Link C . Measuring the urologic iceberg: design and implementation of the Boston Area Community Health (BACH) Survey. Eur Urol. 2007; 52(2):389-96. PMC: 2020848. DOI: 10.1016/j.eururo.2007.03.013. View

17.

Washburn R, Smith K, Jette A, Janney C . The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol. 1993; 46(2):153-62. DOI: 10.1016/0895-4356(93)90053-4. View

18.

Robertson C, Link C, Onel E, Mazzetta C, Keech M, Hobbs R . The impact of lower urinary tract symptoms and comorbidities on quality of life: the BACH and UREPIK studies. BJU Int. 2007; 99(2):347-54. DOI: 10.1111/j.1464-410X.2007.06609.x. View

19.

Barry M, Fowler Jr F, OLeary M, Bruskewitz R, HOLTGREWE H, MEBUST W . The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association. J Urol. 1992; 148(5):1549-57; discussion 1564. DOI: 10.1016/s0022-5347(17)36966-5. View