» Articles » PMID: 19089693

Atherosclerotic Plaque Development and Instability: a Dual Role for VEGF

Overview
Journal Ann Med
Publisher Informa Healthcare
Specialty General Medicine
Date 2008 Dec 18
PMID 19089693
Citations 39
Authors
Affiliations
Soon will be listed here.
Abstract

Vascular endothelial growth factor (VEGF), a potent growth factor for endothelial cells and inducer of angiogenesis, is important for endothelial integrity and thus for vascular function. On the other hand, VEGF may enhance the pathophysiologic mechanism of plaque formation and plaque destabilization. In this review we discuss the data available so far for VEGF as angiogenic and/or inflammatory cytokine in the vulnerable atherosclerotic plaque.

Citing Articles

Network Pharmacology and Experimental Verification: SanQi-DanShen Treats Coronary Heart Disease by Inhibiting the PI3K/AKT Signaling Pathway.

Zhao M, Feng L, Li W Drug Des Devel Ther. 2024; 18:4529-4550.

PMID: 39399124 PMC: 11471080. DOI: 10.2147/DDDT.S480248.


Higher levels of markers for early atherosclerosis in anti-citrullinated protein antibodies positive individuals at risk for RA, a cross sectional study.

Hinkema H, Westra J, Arends S, Brouwer E, Mulder D Rheumatol Int. 2024; 44(10):2007-2016.

PMID: 39012360 PMC: 11393035. DOI: 10.1007/s00296-024-05659-5.


Identification of microRNA biomarkers simultaneously expressed in circulating extracellular vesicles and atherosclerotic plaques.

Brandes F, Meidert A, Kirchner B, Yu M, Gebhardt S, Steinlein O Front Cardiovasc Med. 2024; 11:1307832.

PMID: 38725837 PMC: 11079260. DOI: 10.3389/fcvm.2024.1307832.


Genetic polymorphisms in VEGFA and VEGFR2 genes associated with coronary heart disease susceptibility and severity.

Hajer F, Hana S, Saoussen C, Abdelhak F, Nadia B, Ameni D Mol Biol Rep. 2023; 50(12):10169-10177.

PMID: 37924452 DOI: 10.1007/s11033-023-08899-z.


Giant phagocytes (Gφ) and neutrophil-macrophage hybrids in human carotid atherosclerotic plaques - An activated phenotype.

Lavie L, Si-On E, Hoffman A Front Immunol. 2023; 14:1101569.

PMID: 36911715 PMC: 9998916. DOI: 10.3389/fimmu.2023.1101569.