Whole Saliva Has a Dual Role on the Adherence of Candida Albicans to Polymethylmetacrylate

Overview

Journal Open Dent J

Publisher Bentham Open

Specialty Dentistry

Date 2008 Dec 18

PMID 19088875

Citations 5

Authors

N Elguezabal

J L Maza

S Dorronsoro

J Ponton

Affiliations

Soon will be listed here.

Abstract

Adhesion of Candida albicans to acrylic of dental prostheses or to salivary macromolecules adsorbed on their surface is believed to be a critical event in the development of denture stomatitis. In previous studies our group has shown that adhesion of C. albicans germ tubes to polystyrene is decreased by saliva whereas C. albicans yeast cells adhesion to the same material is enhanced. The results presented in this study confirm this dual role played by whole saliva, since it decreased the adhesion of germ tubes but increased the adhesion of yeast cells to polymethylmetacrylate (PMMA). These effects mediated by whole saliva do not seem to be related to an inhibition of the germination of C. albicans, since similar levels of filamentation were observed in presence and absence of saliva. These results may give new insights into the conflicting role of saliva in the adhesion of C. albicans to acrylic resins of dental prostheses.

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References

McCourtie J, MacFarlane T, Samaranayake L . Effect of saliva and serum on the adherence of Candida species to chlorhexidine-treated denture acrylic. J Med Microbiol. 1986; 21(3):209-13. DOI: 10.1099/00222615-21-3-209. View

Moura J, Silva W, Pereira T, Del Bel Cury A, Rodrigues Garcia R . Influence of acrylic resin polymerization methods and saliva on the adherence of four Candida species. J Prosthet Dent. 2006; 96(3):205-11. DOI: 10.1016/j.prosdent.2006.07.004. View

Elguezabal N, Maza J, Ponton J . Inhibition of adherence of Candida albicans and Candida dubliniensis to a resin composite restorative dental material by salivary secretory IgA and monoclonal antibodies. Oral Dis. 2004; 10(2):81-6. DOI: 10.1046/j.1354-523x.2003.00969.x. View

VASILAS A, Molina L, Hoffman M, Haidaris C . The influence of morphological variation on Candida albicans adhesion to denture acrylic in vitro. Arch Oral Biol. 1992; 37(8):613-22. DOI: 10.1016/0003-9969(92)90123-p. View

Fitzgerald D, Coleman D, OConnell B . Susceptibility of Candida dubliniensis to salivary histatin 3. Antimicrob Agents Chemother. 2002; 47(1):70-6. PMC: 149010. DOI: 10.1128/AAC.47.1.70-76.2003. View

Holmes A, Bandara B, Cannon R . Saliva promotes Candida albicans adherence to human epithelial cells. J Dent Res. 2002; 81(1):28-32. DOI: 10.1177/002203450208100107. View

San Millan R, Elguezabal N, Regulez P, Moragues M, Quindos G, Ponton J . Effect of salivary secretory IgA on the adhesion of Candida albicans to polystyrene. Microbiology (Reading). 2000; 146 ( Pt 9):2105-2112. DOI: 10.1099/00221287-146-9-2105. View

Tronchin G, Bouchara J, Robert R, Senet J . Adherence of Candida albicans germ tubes to plastic: ultrastructural and molecular studies of fibrillar adhesins. Infect Immun. 1988; 56(8):1987-93. PMC: 259512. DOI: 10.1128/iai.56.8.1987-1993.1988. View

Kimura L, Pearsall N . Relationship between germination of Candida albicans and increased adherence to human buccal epithelial cells. Infect Immun. 1980; 28(2):464-8. PMC: 550958. DOI: 10.1128/iai.28.2.464-468.1980. View

10.

Urizar J . [Oral candidiasis]. Rev Iberoam Micol. 2003; 19(1):17-21. View

11.

Budtz-Jorgensen E . The significance of Candida albicans in denture stomatitis. Scand J Dent Res. 1974; 82(2):151-90. DOI: 10.1111/j.1600-0722.1974.tb00378.x. View

12.

Samaranayake L, McCourtie J, MacFarlane T . Factors affecting th in-vitro adherence of Candida albicans to acrylic surfaces. Arch Oral Biol. 1980; 25(8-9):611-5. DOI: 10.1016/0003-9969(80)90076-x. View

13.

Budtz-Jorgensen E . Etiology, pathogenesis, therapy, and prophylaxis of oral yeast infections. Acta Odontol Scand. 1990; 48(1):61-9. DOI: 10.3109/00016359009012735. View

14.

Karaagaclioglu L, Can G, Yilmaz B, Ayhan N, Semiz O, Levent H . The adherence of Candida albicans to acrylic resin reinforced with different fibers. J Mater Sci Mater Med. 2007; 19(2):959-63. DOI: 10.1007/s10856-007-3177-4. View

15.

Marcotte H, Lavoie M . Oral microbial ecology and the role of salivary immunoglobulin A. Microbiol Mol Biol Rev. 1998; 62(1):71-109. PMC: 98907. DOI: 10.1128/MMBR.62.1.71-109.1998. View

16.

Tabak L, LeVine M, MANDEL I, ELLISON S . Role of salivary mucins in the protection of the oral cavity. J Oral Pathol. 1982; 11(1):1-17. DOI: 10.1111/j.1600-0714.1982.tb00138.x. View

17.

San Millan R, Ezkurra P, Quindos G, Robert R, Senet J, Ponton J . Effect of monoclonal antibodies directed against Candida albicans cell wall antigens on the adhesion of the fungus to polystyrene. Microbiology (Reading). 1996; 142 ( Pt 8):2271-7. DOI: 10.1099/13500872-142-8-2271. View

18.

Edgerton M, Scannapieco F, Reddy M, LeVine M . Human submandibular-sublingual saliva promotes adhesion of Candida albicans to polymethylmethacrylate. Infect Immun. 1993; 61(6):2644-52. PMC: 280896. DOI: 10.1128/iai.61.6.2644-2652.1993. View

19.

Maza J, Elguezabal N, Prado C, Ellacuria J, Soler I, Ponton J . Candida albicans adherence to resin-composite restorative dental material: influence of whole human saliva. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002; 94(5):589-92. DOI: 10.1067/moe.2002.126024. View

20.

Manfredi M, Merigo E, Salati A, Conti S, Savi A, Polonelli L . In vitro candidacidal activity of a synthetic killer decapeptide (KP) against Candida albicans cells adhered to resin acrylic discs. J Oral Pathol Med. 2007; 36(8):468-71. DOI: 10.1111/j.1600-0714.2007.00561.x. View