Structural Relationship Between the Vancomycin Resistance Protein VanH and 2-hydroxycarboxylic Acid Dehydrogenases

Overview

Journal Gene

Specialty Molecular Biology

Date 1991 Jul 15

PMID 1908809

Citations 38

Authors

M Arthur

C Molinas

P Courvalin

Affiliations

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Abstract

Sequencing upstream from the vanA gene of enterococcal plasmid pIP816 that confers Vm resistance revealed the presence of an ORF which could code for a protein of 322 aa designated VanH. Extensive aa similarity was detected between VanH and 2-hydroxycarboxylic acid dehydrogenase. We discuss possible roles for VanH in the synthesis of a novel type of peptidoglycan precursors with lower affinity for Vm.

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