Genetic Correlation Between H3N2 Human and Swine Influenza Viruses

Overview

Journal J Clin Virol

Specialty Microbiology

Date 2008 Dec 17

PMID 19083267

Citations 6

Authors

Lei Sun

Guihong Zhang

Yuelong Shu

Xuemei Chen

Yiping Zhu

Limin Yang

Guangpeng Ma

Yoshihiro Kitamura

Wenjun Liu

Affiliations

Soon will be listed here.

Abstract

Background: H3N2 is one of the main subtypes of influenza virus which circulates in human and swine population throughout the world.

Objectives: To investigate the genetic correlation between H3N2 human and swine influenza viruses from the same region during the same season.

Study Design: Five H3N2 human and four H3N2 swine influenza viruses were isolated from Guangdong province of China in the winter of 2005. The molecular evolution of eight gene segments was analyzed.

Results: In the phylogenetic trees of gene segments, all H3N2 human isolates along with the 2000's human isolates formed a cluster, and most of the H3N2 swine isolates along with the 1990's human isolates formed another cluster except that the M and NS gene of A/Swine/Guangdong/01/2005 and the PA gene of A/Swine/Guangdong/02/2005 fell into the cluster of the classical swine influenza virus, indicating the reassortment between H3N2 human and H1N1 swine influenza viruses.

Conclusions: In this study, H3N2 swine influenza viruses in 2005 did not originate from the 2000's H3N2 human influenza viruses, but from the 1990's H3N2 human isolates. In addition, the reassortment of H3N2 human and H1N1 swine influenza virus in pigs was common in recent years.

Citing Articles

Genetic and molecular characterization of a novel reassortant H3N2 influenza virus from a sick pig in Eastern China in 2019.

Yang F, Cheng L, Liu F, Yao H, Wu N, Xu L Vet Res. 2025; 56(1):38.

PMID: 39930519 PMC: 11808988. DOI: 10.1186/s13567-025-01462-7.

A Characterization and an Evolutionary and a Pathogenicity Analysis of Reassortment H3N2 Avian Influenza Virus in South China in 2019-2020.

Liu T, Huang Y, Xie S, Xu L, Chen J, Qi W Viruses. 2022; 14(11).

PMID: 36423183 PMC: 9692712. DOI: 10.3390/v14112574.

Antiviral Action of Methylated β-Lactoglobulin on the Human Influenza Virus A Subtype H3N2.

Sitohy M, Besse B, Billaudel S, Haertle T, Chobert J Probiotics Antimicrob Proteins. 2016; 2(2):104-11.

PMID: 26781119 DOI: 10.1007/s12602-010-9036-5.

Genetic characterization of swine influenza viruses (H3N2) isolated from Minnesota in 2006-2007.

Kumar S, Deflube L, Biswas M, Shobana R, Elankumaran S Virus Genes. 2011; 43(2):161-76.

PMID: 21603982 DOI: 10.1007/s11262-011-0618-4.

Isolation and complete genomic characterization of H1N1 subtype swine influenza viruses in southern China through the 2009 pandemic.

Liu Y, Ji J, Xie Q, Wang J, Shang H, Chen C Virol J. 2011; 8:129.

PMID: 21418598 PMC: 3070672. DOI: 10.1186/1743-422X-8-129.

References

Gregory V, Lim W, Cameron K, Bennett M, Marozin S, Klimov A . Infection of a child in Hong Kong by an influenza A H3N2 virus closely related to viruses circulating in European pigs. J Gen Virol. 2001; 82(Pt 6):1397-1406. DOI: 10.1099/0022-1317-82-6-1397. View

Yu H, Hua R, Zhang Q, Liu T, Liu H, Li G . Genetic evolution of swine influenza A (H3N2) viruses in China from 1970 to 2006. J Clin Microbiol. 2008; 46(3):1067-75. PMC: 2268354. DOI: 10.1128/JCM.01257-07. View

Zhou N, Senne D, Landgraf J, Swenson S, Erickson G, Rossow K . Genetic reassortment of avian, swine, and human influenza A viruses in American pigs. J Virol. 1999; 73(10):8851-6. PMC: 112910. DOI: 10.1128/JVI.73.10.8851-8856.1999. View

Smith T, BURGERT Jr E, Dowdle W, Noble G, Campbell R, Van Scoy R . Isolation of swine influenza virus from autopsy lung tissue of man. N Engl J Med. 1976; 294(13):708-10. DOI: 10.1056/NEJM197603252941308. View

Kida H, Shortridge K, Webster R . Origin of the hemagglutinin gene of H3N2 influenza viruses from pigs in China. Virology. 1988; 162(1):160-6. DOI: 10.1016/0042-6822(88)90405-9. View

OTTIS K, Sidoli L, Bachmann P, Webster R, KAPLAN M . Human influenza A viruses in pigs: isolation of a H3N2 strain antigenically related to A/England/42/72 and evidence for continuous circulation of human viruses in the pig population. Arch Virol. 1982; 73(2):103-8. DOI: 10.1007/BF01314719. View

Shortridge K, Cherry A, Kendal A . Further studies of the antigenic properties of H3N2 strains of influenza A isolated from swine in South East Asia. J Gen Virol. 1979; 44(1):251-4. DOI: 10.1099/0022-1317-44-1-251. View

Nerome K, Ishida M, Nakayama M, Oya A, Kanai C, Suwicha K . Antigenic and genetic analysis of A/Hong Kong (H3N2) influenza viruses isolated from swine and man. J Gen Virol. 1981; 56(Pt 2):441-5. DOI: 10.1099/0022-1317-56-2-441. View

Liu J, Xiao H, Lei F, Zhu Q, Qin K, Zhang X . Highly pathogenic H5N1 influenza virus infection in migratory birds. Science. 2005; 309(5738):1206. DOI: 10.1126/science.1115273. View

10.

de Jong J, Smith D, Lapedes A, Donatelli I, Campitelli L, Barigazzi G . Antigenic and genetic evolution of swine influenza A (H3N2) viruses in Europe. J Virol. 2007; 81(8):4315-22. PMC: 1866135. DOI: 10.1128/JVI.02458-06. View

11.

Zhou N, Senne D, Landgraf J, Swenson S, Erickson G, Rossow K . Emergence of H3N2 reassortant influenza A viruses in North American pigs. Vet Microbiol. 2000; 74(1-2):47-58. DOI: 10.1016/s0378-1135(00)00165-6. View

12.

Shu L, Lin Y, Wright S, Shortridge K, Webster R . Evidence for interspecies transmission and reassortment of influenza A viruses in pigs in southern China. Virology. 1994; 202(2):825-33. DOI: 10.1006/viro.1994.1404. View

13.

Claas E, Kawaoka Y, de Jong J, Masurel N, Webster R . Infection of children with avian-human reassortant influenza virus from pigs in Europe. Virology. 1994; 204(1):453-7. DOI: 10.1006/viro.1994.1553. View

14.

Richt J, Lager K, Janke B, Woods R, Webster R, Webby R . Pathogenic and antigenic properties of phylogenetically distinct reassortant H3N2 swine influenza viruses cocirculating in the United States. J Clin Microbiol. 2003; 41(7):3198-205. PMC: 165376. DOI: 10.1128/JCM.41.7.3198-3205.2003. View

15.

Tumova B, MENSIK J, Stumpa A, FEDOVA D, Pospisil Z . Serological evidence and isolation of a virus closely related to the human A/Hong Kong/68 (H3N2) strain in swine populations in Czechoslovakia in 1969-1972. Zentralbl Veterinarmed B. 1976; 23(7):590-63. View

16.

Qi X, Lu C . Genetic characterization of novel reassortant H1N2 influenza A viruses isolated from pigs in southeastern China. Arch Virol. 2006; 151(11):2289-99. PMC: 7087176. DOI: 10.1007/s00705-006-0796-x. View

17.

Peiris J, Guan Y, Markwell D, Ghose P, Webster R, Shortridge K . Cocirculation of avian H9N2 and contemporary "human" H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment?. J Virol. 2001; 75(20):9679-86. PMC: 114539. DOI: 10.1128/JVI.75.20.9679-9686.2001. View