Tetraspanins: Push and Pull in Suppressing and Promoting Metastasis

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2008 Dec 17

PMID 19078974

Citations 332

Authors

Margot Zoller

Affiliations

Soon will be listed here.

Abstract

Tumours progress through a cascade of events that enable the formation of metastases. Some of the components that are required for this fatal process are well established. Tetraspanins, however, have only recently received attention as both metastasis suppressors and metastasis promoters. This late appreciation is probably due to their capacity to associate with various molecules, which they recruit into special membrane microdomains, and their abundant presence in tumour-derived small vesicles that aid intercellular communication. It is reasonable to assume that differences in the membrane and vesicular web components that associate with individual tetraspanins account for their differing abilities to promote and suppress metastasis.

Citing Articles

Developing anti-TDE vaccine for sensitizing cancer cells to treatment and metastasis control.

Meena S, Kosgei B, Soko G, Tingjun C, Chambuso R, Mwaiselage J NPJ Vaccines. 2025; 10(1):18.

PMID: 39870669 PMC: 11772600. DOI: 10.1038/s41541-024-01035-3.

Relationship between exosomes and cancer: formation, diagnosis, and treatment.

Huang C, Li J, Xie Z, Hu X, Huang Y Int J Biol Sci. 2025; 21(1):40-62.

PMID: 39744442 PMC: 11667803. DOI: 10.7150/ijbs.95763.

The Role of Extracellular Vesicles and Microparticles in Central Nervous System Disorders: Mechanisms, Biomarkers, and Therapeutic Potential.

Najdaghi S, Davani D, Fouladseresht H, Ebrahimi N, Sullman M, Moradi M Cell Mol Neurobiol. 2024; 44(1):82.

PMID: 39625540 PMC: 11614997. DOI: 10.1007/s10571-024-01518-w.

Roles of extracellular vesicles from mesenchymal stem cells in regeneration.

Jung H, Jung Y, Seo J, Bae Y, Kim H, Jeong W Mol Cells. 2024; 47(12):100151.

PMID: 39547584 PMC: 11683238. DOI: 10.1016/j.mocell.2024.100151.

Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in Spinal Cord Injury.

An J, Chen B, Zhang R, Tian D, Shi K, Zhang L Mol Neurobiol. 2024; 62(1):1291-1315.

PMID: 39312070 DOI: 10.1007/s12035-024-04490-0.

References

He B, Liu L, Cook G, Grgurevich S, Jennings L, Zhang X . Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion. J Biol Chem. 2004; 280(5):3346-54. DOI: 10.1074/jbc.M406680200. View

Saito Y, Tachibana I, Takeda Y, Yamane H, He P, Suzuki M . Absence of CD9 enhances adhesion-dependent morphologic differentiation, survival, and matrix metalloproteinase-2 production in small cell lung cancer cells. Cancer Res. 2006; 66(19):9557-65. DOI: 10.1158/0008-5472.CAN-06-1131. View

Stipp C, Kolesnikova T, Hemler M . EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. J Biol Chem. 2001; 276(44):40545-54. DOI: 10.1074/jbc.M107338200. View

Huang C, Ueno M, Liu D, Masuya D, Nakano J, Yokomise H . MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE2. Oncogene. 2006; 25(49):6480-8. DOI: 10.1038/sj.onc.1209654. View

Jackson P, Marreiros A, Russell P . KAI1 tetraspanin and metastasis suppressor. Int J Biochem Cell Biol. 2004; 37(3):530-4. DOI: 10.1016/j.biocel.2004.08.009. View

De Bruyne E, Andersen T, De Raeve H, Van Valckenborgh E, Caers J, Van Camp B . Endothelial cell-driven regulation of CD9 or motility-related protein-1 expression in multiple myeloma cells within the murine 5T33MM model and myeloma patients. Leukemia. 2006; 20(10):1870-9. DOI: 10.1038/sj.leu.2404343. View

Runge K, Evans J, He Z, Gupta S, McDonald K, Stahlberg H . Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution. Dev Biol. 2007; 304(1):317-25. DOI: 10.1016/j.ydbio.2006.12.041. View

Telese F, Bruni P, Donizetti A, Gianni D, DAmbrosio C, Scaloni A . Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET. EMBO Rep. 2004; 6(1):77-82. PMC: 1299219. DOI: 10.1038/sj.embor.7400309. View

Ahmad A, Hart I . Mechanisms of metastasis. Crit Rev Oncol Hematol. 1998; 26(3):163-73. DOI: 10.1016/s1040-8428(97)10002-6. View

10.

Tonoli H, Barrett J . CD82 metastasis suppressor gene: a potential target for new therapeutics?. Trends Mol Med. 2005; 11(12):563-70. DOI: 10.1016/j.molmed.2005.10.002. View

11.

Phillips K, White A, Hicks D, Welch D, Barrett J, Wei L . Correlation between reduction of metastasis in the MDA-MB-435 model system and increased expression of the Kai-1 protein. Mol Carcinog. 1998; 21(2):111-20. View

12.

Todeschini A, Dos Santos J, Handa K, Hakomori S . Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway. Proc Natl Acad Sci U S A. 2008; 105(6):1925-30. PMC: 2538860. DOI: 10.1073/pnas.0709619104. View

13.

Berditchevski F, Odintsova E, Sawada S, Gilbert E . Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling. J Biol Chem. 2002; 277(40):36991-7000. DOI: 10.1074/jbc.M205265200. View

14.

Stipp C, Kolesnikova T, Hemler M . Functional domains in tetraspanin proteins. Trends Biochem Sci. 2003; 28(2):106-12. DOI: 10.1016/S0968-0004(02)00014-2. View

15.

van Niel G, Porto-Carreiro I, Simoes S, Raposo G . Exosomes: a common pathway for a specialized function. J Biochem. 2006; 140(1):13-21. DOI: 10.1093/jb/mvj128. View

16.

Briese J, Schulte H, Sajin M, Bamberger C, Redlin K, Milde-Langosch K . Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas. Virchows Arch. 2008; 453(1):89-96. DOI: 10.1007/s00428-008-0608-7. View

17.

Dong J, Lamb P, Rinker-Schaeffer C, Vukanovic J, Ichikawa T, Isaacs J . KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science. 1995; 268(5212):884-6. DOI: 10.1126/science.7754374. View

18.

Zoller M . Gastrointestinal tumors: metastasis and tetraspanins. Z Gastroenterol. 2006; 44(7):573-86. DOI: 10.1055/s-2006-926795. View

19.

Takeda Y, Kazarov A, Butterfield C, Hopkins B, Benjamin L, Kaipainen A . Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro. Blood. 2006; 109(4):1524-32. PMC: 1794066. DOI: 10.1182/blood-2006-08-041970. View

20.

Herlevsen M, Schmidt D, Miyazaki K, Zoller M . The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation. J Cell Sci. 2003; 116(Pt 21):4373-90. DOI: 10.1242/jcs.00760. View