Basic and Clinical Immunology of Siglecs

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 2008 Dec 17

PMID 19076345

Citations 78

Authors

Stephan von Gunten

Bruce S Bochner

Affiliations

Soon will be listed here.

Abstract

Siglecs are cell-surface proteins found primarily on hematopoietic cells. By definition, they are members of the immunoglobulin gene super-family and bind sialic acid. Most contain cytoplasmic tyrosine motifs implicated in cell signaling. This review will first summarize characteristics common and unique to Siglecs, followed by a discussion of each human Siglec in numerical order, mentioning in turn its closest murine ortholog or paralog. Each section will describe its pattern of cellular expression, latest known immune functions, ligands, and signaling pathways, with the focus being predominantly on CD33-related Siglecs. Potential clinical and therapeutic implications of each Siglec will also be covered.

Citing Articles

Interactions of human milk oligosaccharides with the immune system.

Slater A, Hickey R, Davey G Front Immunol. 2025; 15:1523829.

PMID: 39877362 PMC: 11772441. DOI: 10.3389/fimmu.2024.1523829.

Siglec-1, an easy and contributory inflammation marker in rheumatology.

Boz V, Tesser A, Burlo F, Donadel N, Pastore S, Amaddeo A Clin Transl Immunology. 2024; 13(7):e1520.

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Dissecting the abilities of murine Siglecs to interact with gangliosides.

Schmidt E, Guo X, Bui D, Jung J, Klassen J, Macauley M J Biol Chem. 2024; 300(7):107482.

PMID: 38897567 PMC: 11294694. DOI: 10.1016/j.jbc.2024.107482.

Relationships of SIGLEC family-related lncRNAs with clinical prognosis and tumor immune microenvironment in ovarian cancer.

Jin X, Chen Y, Hu Q Sci Rep. 2024; 14(1):7593.

PMID: 38556590 PMC: 10982283. DOI: 10.1038/s41598-024-57946-7.

Sequence variety in the CC' loop of Siglec-8/9/3 determines the recognitions to sulfated oligosaccharides.

Wang Y, Peng Y, Long R, Shi P, Zhang Y, Kong D Comput Struct Biotechnol J. 2023; 21:4159-4171.

PMID: 37675287 PMC: 10477811. DOI: 10.1016/j.csbj.2023.08.014.

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