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Mesenchymal Stem Cell-mediated Ectopic Hematopoiesis Alleviates Aging-related Phenotype in Immunocompromised Mice

Overview
Journal Blood
Publisher Elsevier
Specialty Hematology
Date 2008 Dec 17
PMID 19074727
Citations 28
Authors
Takayoshi Yamaza
Yasuo Miura
Kentaro Akiyama
Yanming Bi
Wataru Sonoyama
Stan Gronthos
Wanjun Chen
Anh Le
Songtao Shi
Affiliations
Soon will be listed here.
Abstract

Subcutaneous transplants of bone marrow mesenchymal stem cells (BMMSCs) are capable of generating ectopic bone and organizing functional hematopoietic marrow elements in animal models. Here we report that immunocompromised mice received subcutaneous BMMSC transplants using hydroxyapatite tricalcium phosphate as a carrier suppressed age-related degeneration in multiple organs and benefited an increase in life span extension compared with control littermates. The newly organized ectopic bone/marrow system restores active hematopoiesis via the erythropoietin receptor/signal transducer and activator of transcription 5 (Stat5) pathway. Furthermore, the BMMSC recipient mice showed elevated level of Klotho and suppression of insulin-like growth factor I signaling, which may be the mechanism contributing to the alleviation of aging-like phenotypes and prolongation of life in the treated mice. This work reveals that erythropoietin receptor/Stat5 pathway contributes to BMMSC-organized ectopic hematopoiesis, which may offer a treatment paradigm of reversing age-related degeneration of multiple organs in adult immunocompromised mice.

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References
1.
Copland I, Jolicoeur E, Gillis M, Cuerquis J, Eliopoulos N, Annabi B . Coupling erythropoietin secretion to mesenchymal stromal cells enhances their regenerative properties. Cardiovasc Res. 2008; 79(3):405-15. DOI: 10.1093/cvr/cvn090. View
2.
Bartke A, Chandrashekar V, Dominici F, Turyn D, Kinney B, Steger R . Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights. Biogerontology. 2003; 4(1):1-8. DOI: 10.1023/a:1022448532248. View
3.
Prockop D . Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997; 276(5309):71-4. DOI: 10.1126/science.276.5309.71. View
4.
Barbieri M, Bonafe M, Franceschi C, Paolisso G . Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab. 2003; 285(5):E1064-71. DOI: 10.1152/ajpendo.00296.2003. View
5.
Kenyon C . The plasticity of aging: insights from long-lived mutants. Cell. 2005; 120(4):449-60. DOI: 10.1016/j.cell.2005.02.002. View