Astrocytes and Ischemic Injury

Overview

Journal Stroke

Specialties Cardiology & Vascular Diseases
Neurology

Date 2008 Dec 10

PMID 19064795

Citations 138

Authors

Takahiro Takano

Nancyann Oberheim

Maria Luisa Cotrina

Maiken Nedergaard

Affiliations

Soon will be listed here.

Abstract

Ischemic injury is traditionally viewed from an axiomatic perspective of neuronal loss. Yet the ischemic infarct encompasses all cell types, including astrocytes. This review will discuss the idea that astrocytes play a fundamental role in the pathogenesis of ischemic neuronal death. It is proposed that stroke injury is primarily a consequence of the failure of astrocytes to support the essential metabolic needs of neurons. This "gliocentric view" of stroke injury predicts that pharmacological interventions specifically targeting neurons are unlikely to succeed, because it is not feasible to preserve neuronal viability in an environment that fails to meet essential metabolic requirements. Neuroprotective efforts targeting the functional integrity of astrocytes may constitute a superior strategy for future neuroprotection.

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