Central Role of Alpha-synuclein Oligomers in Neurodegeneration in Parkinson Disease

Overview

Journal Arch Neurol

Specialty Neurology

Date 2008 Dec 10

PMID 19064744

Citations 35

Authors

Aleksey G Kazantsev

Alexander M Kolchinsky

Affiliations

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Abstract

Selective death of nigrostriatal neurons, which leads to Parkinson disease, is explained by misfolding of brain protein alpha-synuclein. Herein, we review the data supporting this concept, propose a scheme of events leading to synuclein-induced neuronal death, and discuss protein deacetylase sirtuins as new potential therapeutic targets involved in this process.

Citing Articles

Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson's Disease.

Brembati V, Faustini G, Longhena F, Outeiro T, Bellucci A Int J Mol Sci. 2023; 24(17).

PMID: 37686236 PMC: 10488235. DOI: 10.3390/ijms241713435.

Combined measure of salivary alpha-synuclein species as diagnostic biomarker for Parkinson's disease.

Angius F, Mocci I, Ercoli T, Loy F, Fadda L, Palmas M J Neurol. 2023; 270(11):5613-5621.

PMID: 37552278 PMC: 10576686. DOI: 10.1007/s00415-023-11893-x.

Alpha synuclein post translational modifications: potential targets for Parkinson's disease therapy?.

Brembati V, Faustini G, Longhena F, Bellucci A Front Mol Neurosci. 2023; 16:1197853.

PMID: 37305556 PMC: 10248004. DOI: 10.3389/fnmol.2023.1197853.

Histone Deacetylases as Epigenetic Targets for Treating Parkinson's Disease.

Li Y, Gu Z, Lin S, Chen L, Dzreyan V, Eid M Brain Sci. 2022; 12(5).

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Metabolites and Biomarker Compounds of Neurodegenerative Diseases in Cerebrospinal Fluid.

Wakamatsu K, Chiba Y, Murakami R, Miyai Y, Matsumoto K, Kamada M Metabolites. 2022; 12(4).

PMID: 35448530 PMC: 9031591. DOI: 10.3390/metabo12040343.