Diffuse Changes in Cortical Thickness in Pediatric Moderate-to-severe Traumatic Brain Injury

Overview

Journal J Neurotrauma

Publisher Mary Ann Liebert

Specialties Emergency Medicine
Neurology

Date 2008 Dec 9

PMID 19061377

Citations 46

Authors

Tricia L Merkley

Erin D Bigler

Elisabeth A Wilde

Stephen R McCauley

Jill V Hunter

Harvey S Levin

Affiliations

Soon will be listed here.

Abstract

Generalized whole brain volume loss has been well documented in moderate-to-severe traumatic brain injury (TBI), as has diffuse cerebral atrophy based on magnetic resonance imaging (MRI) volumetric methods where white matter may be more selectively affected than gray matter. However, specific regional differences in gray matter thickness of the cortical mantle have not been previously examined. As such, cortical thickness was assessed using FreeSurfer software to identify regions of significant gray matter cortical thinning in MRI scans of 16 young TBI subjects (age range, 9-16 years) compared to 16 demographically matched controls. Significant cortical thinning was observed globally in the TBI group compared to the cohort of typically developing children. Reduced cortical thickness was related to reported deficits in working memory. TBI-induced cortical thickness reductions are probably due to a combination of focal and diffuse effects and have implications for the neurobehavioral sequelae of TBI.

Citing Articles

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