Chenodeoxycholate is an Inhibitor of Clostridium Difficile Spore Germination

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2008 Dec 9

PMID 19060152

Citations 112

Authors

Joseph A Sorg

Abraham L Sonenshein

Affiliations

Soon will be listed here.

Abstract

Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.

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