Risk Factors for Cardiovascular Disease and Endothelin-1 Levels in Takayasu Arteritis Patients

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2008 Dec 6

PMID 19057845

Citations 6

Authors

Alexandre Wagner Silva de Souza

Henrique Ataide Mariz

Edgard Torres Reis Neto

Anne Elizabeth Diniz Arraes

Neusa Pereira da Silva

Emilia Inoue Sato

Affiliations

Soon will be listed here.

Abstract

The objective of this study was to evaluate traditional risk factors for cardiovascular disease (CVD) and endothelin-1 (ET-1) levels in Takayasu arteritis (TA) patients. Twenty-two TA patients and 37 controls were evaluated. TA patients had a higher prevalence of hypertension (63.6% vs. 21.6%, p=0.001) and higher levels of triglycerides (129.5 mg/dL+/-70.8 vs. 88.4 mg/dL+/-60.8, p=0.017) than controls. Mean number of CVD risk factors was 1.64+/-1.22 in TA patients and 1.03+/-1.44 among controls, p=0.030. More TA patients presented at least one CVD risk factor when compared to controls (77.2% vs. 51.3%, p=0.048). ET-1 levels were higher in patients than in controls (1.49 pg/mL+/-0.45 vs. 1.27 pg/mL+/-0.32, p=0.034), however no significant difference was found between patients with active and inactive disease. In this study, TA patients presented a higher prevalence of hypertension, higher levels of triglycerides, and ET-1 than controls.

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