Changes in Urinary PGE2 After Ibuprofen Treatment in Preterm Infants with Patent Ductus Arteriosus

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 2008 Dec 3

PMID 19048246

Citations 11

Authors

R Antonucci

L Cuzzolin

A Arceri

A Dessi

V Fanos

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate changes in urinary PGE(2) after ibuprofen treatment in preterm infants with patent ductus arteriosus (PDA).

Methods: Twenty preterm infants with a hemodynamically significant PDA (gestational age, 28.6 +/- 2.3 weeks) and 20 controls (gestational age, 30.4 +/- 1.5 weeks) were prospectively enrolled at 48-72 h of life. After enrollment, the former underwent conventional ibuprofen-lysine treatment. At 48-72 h (T(0)) and 108-144 h of life (T(1)), urine samples were noninvasively collected in both groups to measure urinary PGE(2) concentrations (enzyme immunoassay method), and renal function was investigated.

Results: Urinary PGE(2) decreased significantly both in ibuprofen-treated patients (66.95 +/- 16.78 vs. 27.15 +/- 17.92 pg/mL, P < 0.001) and in controls (71.7 +/- 16.2 vs. 53.2 +/- 18.4 pg/mL, P < 0.001) from T(0) to T(1). However, urinary PGE(2) at T(1) was significantly lower (P < 0.001) in the ibuprofen group compared to the control group. Acute renal failure occurred in three ibuprofen-treated patients (15%).

Conclusions: Ibuprofen markedly reduces (59.4%) urinary PGE(2) and may alter renal function in the newborn.

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