Inheritance of Colorectal Cancer

Overview

Journal Drug Discov Today Dis Mech

Publisher Elsevier

Date 2008 Dec 2

PMID 19043597

Citations 22

Authors

Randall Burt

Affiliations

Soon will be listed here.

Abstract

Inheritance is involved in up to one third of colon cancer cases. Highly penetrant inherited syndromes account for approximately 3%, while more common, but less penetrant inherited factors play a role in the remainder. Approaches to recognizing each of these categories and syndromes, using genetic testing for diagnosis where indicated, and accomplishing proper cancer screening and surveillance will be outlined in this review.

Citing Articles

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Teenage-Onset Colorectal Cancers in a Digenic Cancer Predisposition Syndrome Provide Clues for the Interaction between Mismatch Repair and Polymerase δ Proofreading Deficiency in Tumorigenesis.

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