Out of the Jaws of Death: PRMT5 Steers P53

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2008 Dec 2

PMID 19043433

Citations 16

Authors

Shelley L Berger

Affiliations

Soon will be listed here.

Abstract

The tumour suppressor p53 triggers either cell-cycle arrest or apoptosis. Now, arginine methylation joins a panoply of other post-translational modifications that regulate p53. PRMT5 mediates p53 methylation, which disposes the cell to arrest rather than death.

Citing Articles

Phase I/II study of the clinical activity and safety of GSK3326595 in patients with myeloid neoplasms.

Watts J, Minden M, Bachiashvili K, Brunner A, Abedin S, Crossman T Ther Adv Hematol. 2024; 15:20406207241275376.

PMID: 39290981 PMC: 11406655. DOI: 10.1177/20406207241275376.

Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy.

Song B, Yang P, Zhang S Cancer Commun (Lond). 2024; 44(3):297-360.

PMID: 38311377 PMC: 10958678. DOI: 10.1002/cac2.12520.

Carcinogenesis and Prognostic Utility of Arginine Methylation-Related Genes in Hepatocellular Cancer.

Ali W, Xiao W, Hoang H, Cali V, Kajdacsy-Balla A Curr Issues Mol Biol. 2023; 45(12):9422-9430.

PMID: 38132437 PMC: 10742294. DOI: 10.3390/cimb45120591.

Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere.

Mongia P, Toyofuku N, Pan Z, Xu R, Kinoshita Y, Oki K Commun Biol. 2023; 6(1):551.

PMID: 37237082 PMC: 10219947. DOI: 10.1038/s42003-023-04925-9.

Exploiting PRMT5 as a target for combination therapy in mantle cell lymphoma characterized by frequent ATM and TP53 mutations.

Che Y, Liu Y, Yao Y, Hill H, Li Y, Cai Q Blood Cancer J. 2023; 13(1):27.

PMID: 36797243 PMC: 9935633. DOI: 10.1038/s41408-023-00799-6.

References

Chen D, Ma H, Hong H, Koh S, Huang S, Schurter B . Regulation of transcription by a protein methyltransferase. Science. 1999; 284(5423):2174-7. DOI: 10.1126/science.284.5423.2174. View

McBride A, Silver P . State of the arg: protein methylation at arginine comes of age. Cell. 2001; 106(1):5-8. DOI: 10.1016/s0092-8674(01)00423-8. View

Aylon Y, Oren M . Living with p53, dying of p53. Cell. 2007; 130(4):597-600. DOI: 10.1016/j.cell.2007.08.005. View

Levine A, Momand J, Finlay C . The p53 tumour suppressor gene. Nature. 1991; 351(6326):453-6. DOI: 10.1038/351453a0. View

Tang Y, Zhao W, Chen Y, Zhao Y, Gu W . Acetylation is indispensable for p53 activation. Cell. 2008; 133(4):612-26. PMC: 2914560. DOI: 10.1016/j.cell.2008.03.025. View

Burley S . p53: a cellular Achilles' heel revealed. Structure. 1994; 2(9):789-92. DOI: 10.1016/S0969-2126(94)00079-4. View

Holmberg C, Tran S, Eriksson J, Sistonen L . Multisite phosphorylation provides sophisticated regulation of transcription factors. Trends Biochem Sci. 2002; 27(12):619-27. DOI: 10.1016/s0968-0004(02)02207-7. View

Laptenko O, Prives C . Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ. 2006; 13(6):951-61. DOI: 10.1038/sj.cdd.4401916. View

Kruse J, Gu W . SnapShot: p53 posttranslational modifications. Cell. 2008; 133(5):930-30.e1. PMC: 3690516. DOI: 10.1016/j.cell.2008.05.020. View

10.

Barlev N, Liu L, Chehab N, Mansfield K, Harris K, Halazonetis T . Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol Cell. 2002; 8(6):1243-54. DOI: 10.1016/s1097-2765(01)00414-2. View

11.

Huang J, Berger S . The emerging field of dynamic lysine methylation of non-histone proteins. Curr Opin Genet Dev. 2008; 18(2):152-8. DOI: 10.1016/j.gde.2008.01.012. View

12.

Jansson M, Durant S, Cho E, Sheahan S, Edelmann M, Kessler B . Arginine methylation regulates the p53 response. Nat Cell Biol. 2008; 10(12):1431-9. DOI: 10.1038/ncb1802. View

13.

An W, Kim J, Roeder R . Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell. 2004; 117(6):735-48. DOI: 10.1016/j.cell.2004.05.009. View

14.

Prives C, Manley J . Why is p53 acetylated?. Cell. 2002; 107(7):815-8. DOI: 10.1016/s0092-8674(01)00619-5. View

15.

Toledo F, Wahl G . Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer. 2006; 6(12):909-23. DOI: 10.1038/nrc2012. View