Alterations in Oligodendrocyte Proteins, Calcium Homeostasis and New Potential Markers in Schizophrenia Anterior Temporal Lobe Are Revealed by Shotgun Proteome Analysis

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2008 Nov 27

PMID 19034380

Citations 59

Authors

Daniel Martins-de-Souza

Wagner F Gattaz

Andrea Schmitt

Christiane Rewerts

Sergio Marangoni

Jose C Novello

Giuseppina Maccarrone

Christoph W Turck

Emmanuel Dias-Neto

Affiliations

Soon will be listed here.

Abstract

Global proteomic analysis of post-mortem anterior temporal lobe samples from schizophrenia patients and non-schizophrenia individuals was performed using stable isotope labeling and shotgun proteomics. Our analysis resulted in the identification of 479 proteins, 37 of which showed statistically significant differential expression. Pathways affected by differential protein expression include transport, signal transduction, energy pathways, cell growth and maintenance and protein metabolism. The collection of protein alterations identified here reinforces the importance of myelin/oligodendrocyte and calcium homeostasis in schizophrenia, and reveals a number of new potential markers that may contribute to the understanding of the pathogenesis of this complex disease.

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