Guidelines for Detection, Management and Prevention of Hyperbilirubinemia in Term and Late Preterm Newborn Infants (35 or More Weeks' Gestation) - Summary

Overview

Journal Paediatr Child Health

Publisher Oxford University Press

Specialty Pediatrics

Date 2008 Nov 26

PMID 19030400

Citations 37

Affiliations

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Abstract

Hyperbilirubinemia is very common and usually benign in the term newborn infant and the late preterm infant at 35 and 36 completed weeks' gestation. Critical hyperbilirubinemia is uncommon but has the potential for causing long-term neurological impairment. Early discharge of the healthy newborn infant, particularly those in whom breastfeeding may not be fully established, may be associated with delayed diagnosis of significant hyperbilirubinemia. Guidelines for the prediction, prevention, identification, monitoring and treatment of severe hyperbilirubinemia are presented.

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References

Kaplan M, Beutler E, Vreman H, Hammerman C, Levy-Lahad E, Renbaum P . Neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes. Pediatrics. 1999; 104(1 Pt 1):68-74. DOI: 10.1542/peds.104.1.68. View

Powell J, Keffler S, Kelly D, Green A . Population screening for neonatal liver disease: potential for a community-based programme. J Med Screen. 2003; 10(3):112-6. DOI: 10.1177/096914130301000303. View

Alcock G, Liley H . Immunoglobulin infusion for isoimmune haemolytic jaundice in neonates. Cochrane Database Syst Rev. 2002; (3):CD003313. DOI: 10.1002/14651858.CD003313. View

Leslie G, Philips 3rd J, CASSADY G . Capillary and venous bilirubin values. Are they really different?. Am J Dis Child. 1987; 141(11):1199-200. DOI: 10.1001/archpedi.1987.04460110069024. View

Rubaltelli F, Gourley G, Loskamp N, Modi N, Roth-Kleiner M, Sender A . Transcutaneous bilirubin measurement: a multicenter evaluation of a new device. Pediatrics. 2001; 107(6):1264-71. DOI: 10.1542/peds.107.6.1264. View

Martinez J, Maisels M, Otheguy L, Garcia H, Savorani M, Mogni B . Hyperbilirubinemia in the breast-fed newborn: a controlled trial of four interventions. Pediatrics. 1993; 91(2):470-3. View

Sgro M, Campbell D, Shah V . Incidence and causes of severe neonatal hyperbilirubinemia in Canada. CMAJ. 2006; 175(6):587-90. PMC: 1559442. DOI: 10.1503/cmaj.060328. View

. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004; 114(1):297-316. DOI: 10.1542/peds.114.1.297. View

SISSON T, Kendall N, Shaw E . Phototherapy of jaundice in the newborn infant. II. Effect of various light intensities. J Pediatr. 1972; 81(1):35-8. DOI: 10.1016/s0022-3476(72)80370-6. View

10.

Bhutani V, Johnson L, Sivieri E . Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. 1999; 103(1):6-14. DOI: 10.1542/peds.103.1.6. View

11.

Bhutani V, Johnson L, Jeffrey Maisels M, Newman T, Phibbs C, Stark A . Kernicterus: epidemiological strategies for its prevention through systems-based approaches. J Perinatol. 2004; 24(10):650-62. DOI: 10.1038/sj.jp.7211152. View

12.

Maisels M, Newman T . Kernicterus in otherwise healthy, breast-fed term newborns. Pediatrics. 1995; 96(4 Pt 1):730-3. View

13.

Brown A, Kim M, Wu P, Bryla D . Efficacy of phototherapy in prevention and management of neonatal hyperbilirubinemia. Pediatrics. 1985; 75(2 Pt 2):393-400. View

14.

Maisels M, Newman T . Jaundice in full-term and near-term babies who leave the hospital within 36 hours. The pediatrician's nemesis. Clin Perinatol. 1998; 25(2):295-302. View

15.

Newman T, Liljestrand P, Escobar G . Combining clinical risk factors with serum bilirubin levels to predict hyperbilirubinemia in newborns. Arch Pediatr Adolesc Med. 2005; 159(2):113-9. DOI: 10.1001/archpedi.159.2.113. View

16.

Jeffrey Maisels M, Ostrea Jr E, Touch S, Clune S, Cepeda E, Kring E . Evaluation of a new transcutaneous bilirubinometer. Pediatrics. 2004; 113(6):1628-35. DOI: 10.1542/peds.113.6.1628. View

17.

Maisels M, Gifford K . Breast-feeding, weight loss, and jaundice. J Pediatr. 1983; 102(1):117-8. DOI: 10.1016/s0022-3476(83)80305-9. View

18.

Kaplan M, Herschel M, Hammerman C, Karrison T, Hoyer J, Stevenson D . Studies in hemolysis in glucose-6-phosphate dehydrogenase-deficient African American neonates. Clin Chim Acta. 2005; 365(1-2):177-82. DOI: 10.1016/j.cca.2005.08.015. View

19.

Sarici S, Yurdakok M, Serdar M, Oran O, Erdem G, Tekinalp G . An early (sixth-hour) serum bilirubin measurement is useful in predicting the development of significant hyperbilirubinemia and severe ABO hemolytic disease in a selective high-risk population of newborns with ABO incompatibility. Pediatrics. 2002; 109(4):e53. DOI: 10.1542/peds.109.4.e53. View

20.

Penn A, Enzmann D, Hahn J, Stevenson D . Kernicterus in a full term infant. Pediatrics. 1994; 93(6 Pt 1):1003-6. View