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Human Embryonic Stem Cells Reveal Recurrent Genomic Instability at 20q11.21

Overview
Journal Nat Biotechnol
Specialty Biotechnology
Date 2008 Nov 26
PMID 19029913
Citations 103
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Abstract

By analyzing five human embryonic stem (hES) cell lines over long-term culture, we identified a recurrent genomic instability in the human genome. An amplification of 2.5-4.6 Mb at 20q11.21, encompassing approximately 23 genes in common, was detected in four cell lines of different origins. This amplification, which has been associated with oncogenic transformation, may provide a selective advantage to hES cells in culture.

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