Iron-enhanced Paraquat-mediated Dopaminergic Cell Death Due to Increased Oxidative Stress As a Consequence of Microglial Activation

Overview

Journal Free Radic Biol Med

Specialties Biochemistry
Biology
General Medicine

Date 2008 Nov 26

PMID 19027846

Citations 36

Authors

Jun Peng

Fang Feng Stevenson

May Lin Oo

Julie K Andersen

Affiliations

Soon will be listed here.

Abstract

Environmental paraquat and neonatal iron exposure have both separately been suggested as potential risk factors for sporadic forms of Parkinson's disease (PD). In this study, we demonstrate that combined environmental exposure to these two agents results in modulations in microglial activation state. Apocynin, an NADPH oxidase inhibitor, was found to attenuate the release of superoxide from microglia stimulated by combined paraquat and iron and blocked paraquat-induced dopaminergic neuronal death. Furthermore, pretreatment with the synthetic superoxide dismutase/catalase mimetic, EUK-189, significantly decreased microglial activation mediated by combined paraquat and iron treatment. These findings support the notion that environmental PD risk factors may act synergetically to produce neurodegeneration associated with the disorder and that iron and paraquat may act via common oxidative stress-mediated mechanism involving microglial activation.

Citing Articles

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Effect of cyanocobalamin (vitamin B12) on paraquat-induced brain injury in mice.

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Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson's Disease.

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The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.

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Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD.

Zuo Y, Xie J, Li X, Li Y, Thirupathi A, Zhang J Oxid Med Cell Longev. 2021; 2021:9961628.

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