Age-related Macular Degeneration: Activation of Innate Immunity System Via Pattern Recognition Receptors

Overview

Journal J Mol Med (Berl)

Specialty General Medicine

Date 2008 Nov 15

PMID 19009282

Citations 37

Authors

K Kaarniranta

A Salminen

Affiliations

Soon will be listed here.

Abstract

Age-related macular degeneration (AMD) is the most common cause of irreversible loss of central vision. Histopathological studies have demonstrated that inflammation is the key player in the pathogenesis of AMD. Genetic studies have revealed that complement factor H is a strong risk factor for the development of AMD. However, innate immunity defence involves several other pattern recognition receptors (PRRs) which can trigger inflammatory responses. Retinal pigment epithelial (RPE) cells have the main role in the immune defence in macula. In this study, we examine in detail the endogenous danger signals which can activate different PRRs in RPE cells, such as Toll-like, NOD-like and scavenger receptors along with complement system. We also characterise the signalling pathways triggered by PRRs in evoking inflammatory responses. In addition, we will discuss whether AMD pathology could represent the outcome of chronic activation of the innate immunity defence in human macula.

Citing Articles

Integrating Multi-omics to Identify Age-Related Macular Degeneration Subtypes and Biomarkers.

Zhang S, Yang Y, Chen J, Su S, Cai Y, Yang X J Mol Neurosci. 2024; 74(3):74.

PMID: 39107525 PMC: 11303511. DOI: 10.1007/s12031-024-02249-9.

The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome.

Brandli A, Vessey K, Fletcher E J Neuroinflammation. 2024; 21(1):64.

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Resveratrol and quercetin protect from Benzo(a)pyrene-induced autophagy in retinal pigment epithelial cells.

Kasikci M, Sen S Int Ophthalmol. 2024; 44(1):12.

PMID: 38319442 DOI: 10.1007/s10792-024-02957-6.

Association of NLRPs with pathogenesis of dry age-related macular degeneration.

Zeng Y, Dong W, Zhang W, Deng B Int Ophthalmol. 2023; 43(12):4869-4878.

PMID: 37936001 DOI: 10.1007/s10792-023-02889-7.

Stages, pathogenesis, clinical management and advancements in therapies of age-related macular degeneration.

Shome I, Thathapudi N, Aramati B, Kowtharapu B, Jangamreddy J Int Ophthalmol. 2023; 43(10):3891-3909.

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