Gastroduodenal Mucosal Defense

Overview

Journal Curr Gastroenterol Rep

Specialty Gastroenterology

Date 2008 Nov 14

PMID 19006609

Citations 5

Authors

Amy Zhu

Jonathan Kaunitz

Affiliations

Soon will be listed here.

Abstract

The gastroduodenal mucosa withstands injury from acid, drugs, foodstuffs, and other factors. Defense mechanisms include pre-epithelial and epithelial barriers, submucosal acid sensors, prostaglandin generation, endogenous protective gases, and other chemical mediators. Recent studies have focused on proteinase-activated receptors and their linkage to prostaglandin formation, as well as on antioxidants targeted to reduce harmful reactive oxygen species. Investigation continues into the protective roles of calcitonin gene-related peptide, hydrogen sulfide, annexin-1, survivin, and methylnicotinamide. This article also summarizes some new findings on the genetics of ulcer formation and the effects of age and gender on mucosal defense and touches on current developments in drugs, including considerations for future therapeutic agents.

Citing Articles

Alterations in Gastric Mucosal Expression of Calcitonin Gene-Related Peptides, Vanilloid Receptors, and Heme Oxygenase-1 Mediate Gastroprotective Action of Carbon Monoxide against Ethanol-Induced Gastric Mucosal Lesions.

Magierowska K, Wojcik D, Chmura A, Bakalarz D, Wierdak M, Kwiecien S Int J Mol Sci. 2018; 19(10).

PMID: 30274172 PMC: 6213448. DOI: 10.3390/ijms19102960.

Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing.

Magierowski M, Magierowska K, Kwiecien S, Brzozowski T Molecules. 2015; 20(5):9099-123.

PMID: 25996214 PMC: 6272495. DOI: 10.3390/molecules20059099.

Are alterations of tight junctions at molecular and ultrastructural level different in duodenal biopsies of patients with celiac disease and Crohn's disease?.

Goswami P, Das P, Verma A, Prakash S, Das T, Nag T Virchows Arch. 2014; 465(5):521-30.

PMID: 25240724 DOI: 10.1007/s00428-014-1651-1.

Red ginseng abrogates oxidative stress via mitochondria protection mediated by LKB1-AMPK pathway.

Dong G, Jang E, Kang S, Cho I, Park S, Kim S BMC Complement Altern Med. 2013; 13:64.

PMID: 23506615 PMC: 3635924. DOI: 10.1186/1472-6882-13-64.

Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam.

Hampton D, Hale L PLoS One. 2011; 6(8):e23669.

PMID: 21858200 PMC: 3155563. DOI: 10.1371/journal.pone.0023669.

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