Tissue Engineering and the Intervertebral Disc: the Challenges

Overview

Journal Eur Spine J

Specialty Orthopedics

Date 2008 Nov 14

PMID 19005701

Citations 73

Authors

Rita Kandel

Sally Roberts

Jill P G Urban

Affiliations

Soon will be listed here.

Abstract

Disc degeneration is a common disorder. Although the back pain that can develop in association with this is rarely life-threatening, the annual cost in terms of morbidity, lost productivity, medical expenses and workers' compensation benefits is significant. Surgical intervention as practised currently is directed towards removing the damaged or altered tissue. Development of new treatment modalities is critical as there is a growing consensus that the strategies used currently for symptomatic degenerative disc disease may not be effective. Accordingly, there is a need to develop an entirely new way to treat this disorder; regenerative medicine and tissue engineering approaches appear particularly promising in this regard. This paper reviews some of the challenges that currently are limiting the clinical application of this approach to the treatment of disc degeneration.

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References

Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T . Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol. 2007; 26(1):101-6. DOI: 10.1038/nbt1374. View

Roberts S, Evans E, Kletsas D, Jaffray D, Eisenstein S . Senescence in human intervertebral discs. Eur Spine J. 2006; 15 Suppl 3:S312-6. PMC: 2335374. DOI: 10.1007/s00586-006-0126-8. View

Mirza S, Deyo R . Systematic review of randomized trials comparing lumbar fusion surgery to nonoperative care for treatment of chronic back pain. Spine (Phila Pa 1976). 2007; 32(7):816-23. DOI: 10.1097/01.brs.0000259225.37454.38. View

Wang Y, Huso D, Harrington J, Kellner J, Jeong D, Turney J . Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture. Cytotherapy. 2005; 7(6):509-19. DOI: 10.1080/14653240500363216. View

Trout J, Buckwalter J, Moore K, Landas S . Ultrastructure of the human intervertebral disc. I. Changes in notochordal cells with age. Tissue Cell. 1982; 14(2):359-69. DOI: 10.1016/0040-8166(82)90033-7. View

Schallmoser K, Bartmann C, Rohde E, Reinisch A, Kashofer K, Stadelmeyer E . Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells. Transfusion. 2007; 47(8):1436-46. DOI: 10.1111/j.1537-2995.2007.01220.x. View

Gruber H, Ingram J, Davis D, Hanley Jr E . Increased cell senescence is associated with decreased cell proliferation in vivo in the degenerating human annulus. Spine J. 2008; 9(3):210-5. DOI: 10.1016/j.spinee.2008.01.012. View

Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L . Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994; 331(14):889-95. DOI: 10.1056/NEJM199410063311401. View

Vernengo J, Fussell G, Smith N, Lowman A . Evaluation of novel injectable hydrogels for nucleus pulposus replacement. J Biomed Mater Res B Appl Biomater. 2007; 84(1):64-9. DOI: 10.1002/jbm.b.30844. View

10.

Adams M, Roughley P . What is intervertebral disc degeneration, and what causes it?. Spine (Phila Pa 1976). 2006; 31(18):2151-61. DOI: 10.1097/01.brs.0000231761.73859.2c. View

11.

Masuda K, Aota Y, Muehleman C, Imai Y, Okuma M, Thonar E . A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration. Spine (Phila Pa 1976). 2005; 30(1):5-14. DOI: 10.1097/01.brs.0000148152.04401.20. View

12.

Zhang Y, Guo X, Xu P, Kang L, Li J . Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans. Clin Orthop Relat Res. 2005; (430):219-26. DOI: 10.1097/01.blo.0000146534.31120.cf. View

13.

Luk K, Ruan D, Chow D, Leong J . Intervertebral disc autografting in a bipedal animal model. Clin Orthop Relat Res. 1997; (337):13-26. DOI: 10.1097/00003086-199704000-00003. View

14.

Bibby S, Jones D, Ripley R, Urban J . Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells. Spine (Phila Pa 1976). 2005; 30(5):487-96. DOI: 10.1097/01.brs.0000154619.38122.47. View

15.

Hiyama A, Mochida J, Iwashina T, Omi H, Watanabe T, Serigano K . Transplantation of mesenchymal stem cells in a canine disc degeneration model. J Orthop Res. 2008; 26(5):589-600. DOI: 10.1002/jor.20584. View

16.

Frick S, Hanley Jr E, Meyer Jr R, Ramp W, Chapman T . Lumbar intervertebral disc transfer. A canine study. Spine (Phila Pa 1976). 1994; 19(16):1826-34; discussion 1834-5. DOI: 10.1097/00007632-199408150-00006. View

17.

Korecki C, Costi J, Iatridis J . Needle puncture injury affects intervertebral disc mechanics and biology in an organ culture model. Spine (Phila Pa 1976). 2008; 33(3):235-41. PMC: 2587060. DOI: 10.1097/BRS.0b013e3181624504. View

18.

Steck E, Bertram H, Abel R, Chen B, Winter A, Richter W . Induction of intervertebral disc-like cells from adult mesenchymal stem cells. Stem Cells. 2005; 23(3):403-11. DOI: 10.1634/stemcells.2004-0107. View

19.

Menezes N, Gray M, Hartke J, Burstein D . T2 and T1rho MRI in articular cartilage systems. Magn Reson Med. 2004; 51(3):503-9. DOI: 10.1002/mrm.10710. View

20.

Chen J, Yan W, Setton L . Molecular phenotypes of notochordal cells purified from immature nucleus pulposus. Eur Spine J. 2006; 15 Suppl 3:S303-11. PMC: 2335373. DOI: 10.1007/s00586-006-0088-x. View