Influence of Common and Specific HLA-DRB1/DQB1 Haplotypes on Genetic Susceptibilities of Three Distinct Arab Populations to Type 1 Diabetes

Overview

Journal Clin Vaccine Immunol

Publisher American Society for Microbiology

Specialties Allergy & Immunology
Pathology

Date 2008 Nov 14

PMID 19005023

Citations 11

Authors

Mouna Stayoussef

Jihen Benmansour

Fayza A Al-Jenaidi

Rita Nemr

Muhallab E Ali

Touhami Mahjoub

Wassim Y Almawi

Affiliations

Soon will be listed here.

Abstract

The contribution of HLA DRB-DQB to type 1 diabetes (T1D) in Bahrainis, Lebanese, and Tunisians was investigated. DRB1*030101-DQB1*0201 was a locus that conferred susceptibility in three populations, while DRB1*040101-DQB1*0302 was a locus that conferred susceptibility only in Tunisians and Bahrainis. The DRB1*100101-DQB1*050101 (Bahrainis) and DRB1*150101-DQB1*060101 (Lebanese) loci were largely protective. The contribution of HLA to T1D must be evaluated with regard to ethnic background.

Citing Articles

Association between alleles, haplotypes, and amino acid variations in HLA class II genes and type 1 diabetes in Kuwaiti children.

Dashti M, Nizam R, Jacob S, Al-Kandari H, Al Ozairi E, Thanaraj T Front Immunol. 2023; 14:1238269.

PMID: 37638053 PMC: 10457110. DOI: 10.3389/fimmu.2023.1238269.

HLA-DRB1 and -DQB1 Alleles, Haplotypes and Genotypes in Emirati Patients with Type 1 Diabetes Underscores the Benefits of Evaluating Understudied Populations.

Al Yafei Z, Mack S, Alvares M, Ali B, Afandi B, Beshyah S Front Genet. 2022; 13:841879.

PMID: 35419034 PMC: 8997289. DOI: 10.3389/fgene.2022.841879.

HLA-DQA1 and HLA-DQB1 Gene Polymorphism in Indonesian Children with Type I Diabetes Mellitus.

Soetjipto , Rochmah N, Faizi M, Hisbiyah Y, Endaryanto A Appl Clin Genet. 2022; 15:11-17.

PMID: 35046698 PMC: 8763574. DOI: 10.2147/TACG.S348115.

Segregation Analysis of Genotyped and Family-Phased, Long Range MHC Classical Class I and Class II Haplotypes in 5 Families With Type 1 Diabetes Proband in the United Arab Emirates.

Tay G, Al Naqbi H, Mawart A, Baalfaqih Z, Almaazmi A, Deeb A Front Genet. 2021; 12:670844.

PMID: 34276777 PMC: 8278101. DOI: 10.3389/fgene.2021.670844.

Human Leukocyte Antigen (HLA) and Islet Autoantibodies Are Tools to Characterize Type 1 Diabetes in Arab Countries: Emphasis on Kuwait.

Jahromi M, Al-Ozairi E Dis Markers. 2019; 2019:9786078.

PMID: 31827651 PMC: 6886320. DOI: 10.1155/2019/9786078.

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