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Origin of Contractile Force During Cell Division of Bacteria

Overview
Journal Phys Rev Lett
Specialty Biophysics
Date 2008 Nov 13
PMID 18999788
Citations 18
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Abstract

When a bacterium divides, its cell wall at the division site grows radially inward like the shutter of a camera and guillotines the cell into two halves. The wall is pulled upon from inside by a polymeric ring, which itself shrinks in radius. The ring is made of an intracellular protein FtsZ (filamenting temperature sensitive Z) and thus is called the Z ring. It is not understood how the Z ring generates the required contractile force. We propose a theoretical model and simulate it to show how the natural curvature of the FtsZ filaments and lateral attraction among them may facilitate force generation.

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