Sequence of the Beta-subunit of the Phosphatidylinositol-specific Phospholipase C-directed GTP-binding Protein from Squid (Loligo Forbesi) Photoreceptors

Overview

Journal Biochem J

Specialty Biochemistry

Date 1991 Jan 1

PMID 1899186

Citations 12

Authors

N J Ryba

J D Pottinger

J N Keen

J B Findlay

Affiliations

Soon will be listed here.

Abstract

The beta-subunit (G-beta) of the squid (Loligo forbesi) visual GTP-binding protein (G-protein), thought to be associated with a phosphatidylinositol-specific phospholipase C, has been identified and the sequence of the protein determined from its cDNA. The predicted polypeptide has a very marked sequence similarity with its mammalian counterparts (80-90% identity). Squid G-beta also has somewhat lower similarity to the yeast protein STE4 (approx. 40% identity). The role of G-beta in signal transduction is discussed in the light of its pronounced structural conservation.

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