Epstein-Barr Virus Encephalitis Presenting with a Tumor-like Lesion in an Immunosuppressed Transplant Recipient

Overview

Journal J Neurovirol

Publisher Springer

Specialties Microbiology
Neurology

Date 2008 Nov 11

PMID 18991070

Citations 9

Authors

Michael Khalil

Christian Enzinger

Mirja Wallner-Blazek

Michael Scarpatetti

Alain Barth

Sabine Horn

Gudrun Reiter

Affiliations

Soon will be listed here.

Abstract

Epstein-Barr virus (EBV) associated central nervous system (CNS) infection is a rare disease. We report an atypical manifestation of EBV encephalitis initially presenting with a tumor-like lesion of the optic tract in an immunocompromised patient 8 years after a combined kidney and pancreas transplantation had been performed. Polymerase chain reaction (PCR) in the cerebrospinal fluid (CSF) and antibody testing confirmed the diagnosis of EBV encephalitis, most likely as a consequence of a reactivated persistent EBV infection. After cessation of the immunosuppressive therapy and induction of treatment with ganciclovir, clinical and magnetic resonance imaging (MRI) findings rapidly improved.

Citing Articles

Epstein-Barr Virus Encephalitis: A Review of Case Reports from the Last 25 Years.

Peuchmaur M, Voisin J, Vaillant M, Truffot A, Lupo J, Morand P Microorganisms. 2023; 11(12).

PMID: 38137968 PMC: 10745555. DOI: 10.3390/microorganisms11122825.

Unpacking the CNS Manifestations of Epstein-Barr Virus: An Imaging Perspective.

Soni N, Ora M, Singh R, Mehta P, Agarwal A, Bathla G AJNR Am J Neuroradiol. 2023; 44(9):1002-1008.

PMID: 37500288 PMC: 10494941. DOI: 10.3174/ajnr.A7945.

The spectrum of Epstein-Barr virus infections of the central nervous system after organ transplantation.

Ridha M, Jones D, Lerner D, Vytopil M, Voetsch B, Burns J Virol J. 2021; 18(1):162.

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An Autopsy Case of Varicella Zoster Virus Encephalitis with Multiple Brain Lesions.

Suzuki T, Tetsuka S, Ogawa T, Hashimoto R, Okada S, Kato H Intern Med. 2020; 59(13):1643-1647.

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Post-transplant primary central nervous system lymphoma after Epstein-Barr virus cerebellitis.

Valencia-Sanchez C, Steenerson K, Kelemen K, Orenstein R, Kusne S, Grill M J Neurovirol. 2019; 25(2):280-283.

PMID: 30607891 DOI: 10.1007/s13365-018-0711-8.

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