Acute Lymphoblastic Leukemia and Obesity: Increased Energy Intake or Decreased Physical Activity?

Overview

Journal Support Care Cancer

Specialties Critical Care
Oncology

Date 2008 Nov 8

PMID 18989711

Citations 29

Authors

H Jansen

A Postma

R P Stolk

W A Kamps

Affiliations

Soon will be listed here.

Abstract

Background: Obesity is a well-known problem in children with acute lymphoblastic leukemia (ALL), and it might be the result of an excess in energy intake, reduced energy expenditure, or both. The aim of this study is to describe energy intake and physical activity during treatment for ALL with intermittent dexamethasone (DEXA).

Methods: Body mass index (BMI), energy intake, and physical activity were measured in 16 ALL patients on maintenance treatment and in 17 healthy controls. ALL patients were measured during ("on DEXA") and in between ("off DEXA") DEXA treatments.

Results: In patients, the mean increase in BMI z-score was 1.4 +/- 1.1. Energy intake on DEXA was higher (2,125.9 +/- 476.0 vs 1,775.1 +/- 426.1 kcal/24 h, p < 0.05) and energy intake off DEXA was lower (1,305.0 +/- 249.4 vs 1,775.1 +/- 426.1 kcal/24 h, p < 0.05), compared to healthy controls. Physical activity on DEXA was lower compared to healthy controls (30.0 +/- 3.9 vs 40.0 +/- 6.0 kcal kg(-1) 24 h(-1), p < 0.001 and 7,303.1 +/- 4,622.9 vs 13,927.2 +/- 3,822.7 steps, p < 0.05). Physical activity off DEXA was not different compared to healthy controls.

Conclusion: Weight gain in patients on ALL treatment might be owing to increased energy intake and decreased physical activity during treatment with DEXA.

Citing Articles

Nutritional interventions in children with acute lymphoblastic leukemia undergoing antineoplastic treatment: a systematic review.

Guzman-Leon A, Avila-Prado J, Bracamontes-Picos L, Haby M, Stein K, Astiazaran-Garcia H BMC Nutr. 2024; 10(1):89.

PMID: 38898513 PMC: 11186292. DOI: 10.1186/s40795-024-00892-4.

Alterations of Nutritional Status in Children and Adolescents with Acute Lymphoblastic Leukemia.

Kranjcec I, Pranjic I, Roganovic J, Pavlovic M, Rajacic N, Sila S Children (Basel). 2024; 11(3).

PMID: 38539369 PMC: 10969479. DOI: 10.3390/children11030334.

The evolution of nutritional care in children and young people with acute lymphoblastic leukaemia: a narrative review.

Lovell A, Gardiner B, Henry L, Bate J, Brougham M, Revuelta Iniesta R J Hum Nutr Diet. 2024; 38(1):e13273.

PMID: 38185902 PMC: 11589404. DOI: 10.1111/jhn.13273.

Body mass trajectory from diagnosis to the end of treatment in a pediatric acute lymphoblastic leukemia cohort.

Galati P, Rocha P, Gruezo N, Amato A Sci Rep. 2023; 13(1):13590.

PMID: 37604919 PMC: 10442422. DOI: 10.1038/s41598-023-39287-z.

Cardiovascular Risk in Childhood Cancer Survivors.

Mainieri F, Giannini C, Chiarelli F Biomedicines. 2022; 10(12).

PMID: 36551851 PMC: 9775574. DOI: 10.3390/biomedicines10123098.

References

Mayer E, Reuter M, Dopfer R, Ranke M . Energy expenditure, energy intake and prevalence of obesity after therapy for acute lymphoblastic leukemia during childhood. Horm Res. 2000; 53(4):193-9. DOI: 10.1159/000023566. View

Sainsbury C, Newcombe R, Hughes I . Weight gain and height velocity during prolonged first remission from acute lymphoblastic leukaemia. Arch Dis Child. 1985; 60(9):832-6. PMC: 1777474. DOI: 10.1136/adc.60.9.832. View

Aznar S, Webster A, San Juan A, Chamorro-Vina C, Mate-Munoz J, Moral S . Physical activity during treatment in children with leukemia: a pilot study. Appl Physiol Nutr Metab. 2006; 31(4):407-13. DOI: 10.1139/h06-014. View

Warner J, Bell W, Webb D, Gregory J . Daily energy expenditure and physical activity in survivors of childhood malignancy. Pediatr Res. 1998; 43(5):607-13. DOI: 10.1203/00006450-199805000-00008. View

Bond S, Han A, Wootton S, Kohler J . Energy intake and basal metabolic rate during maintenance chemotherapy. Arch Dis Child. 1992; 67(2):229-32. PMC: 1793405. DOI: 10.1136/adc.67.2.229. View

Jarfelt M, Lannering B, Bosaeus I, Johannsson G, Bjarnason R . Body composition in young adult survivors of childhood acute lymphoblastic leukaemia. Eur J Endocrinol. 2005; 153(1):81-9. DOI: 10.1530/eje.1.01931. View

Reilly J, Ventham J, Ralston J, Donaldson M, Gibson B . Reduced energy expenditure in preobese children treated for acute lymphoblastic leukemia. Pediatr Res. 1998; 44(4):557-62. DOI: 10.1203/00006450-199810000-00015. View

Ainsworth B, Haskell W, Whitt M, Irwin M, Swartz A, Strath S . Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000; 32(9 Suppl):S498-504. DOI: 10.1097/00005768-200009001-00009. View

Fredriks A, Buuren S, Wit J, Verloove-Vanhorick S . Body index measurements in 1996-7 compared with 1980. Arch Dis Child. 2000; 82(2):107-12. PMC: 1718204. DOI: 10.1136/adc.82.2.107. View

10.

Beets M, Patton M, Edwards S . The accuracy of pedometer steps and time during walking in children. Med Sci Sports Exerc. 2005; 37(3):513-20. DOI: 10.1249/01.mss.0000155395.49960.31. View

11.

Reilly J, BROUGHAM M, Montgomery C, Richardson F, Kelly A, Gibson B . Effect of glucocorticoid therapy on energy intake in children treated for acute lymphoblastic leukemia. J Clin Endocrinol Metab. 2001; 86(8):3742-5. DOI: 10.1210/jcem.86.8.7764. View

12.

Hokken-Koelega A, Hahlen K, de GROOT A, Tromp C, Egeler R . Obesity after successful treatment of acute lymphoblastic leukemia in childhood. Pediatr Res. 1995; 38(1):86-90. DOI: 10.1203/00006450-199507000-00015. View

13.

Davies J, Evans B, Jones E, Evans W, Jenney M, Gregory J . Osteopenia, excess adiposity and hyperleptinaemia during 2 years of treatment for childhood acute lymphoblastic leukaemia without cranial irradiation. Clin Endocrinol (Oxf). 2004; 60(3):358-65. DOI: 10.1111/j.1365-2265.2003.01986.x. View