The Emerging Role of MicroRNAs in Cardiac Remodeling and Heart Failure

Overview

Journal Circ Res

Specialty Cardiology & Vascular Diseases

Date 2008 Nov 8

PMID 18988904

Citations 123

Authors

Vijay Divakaran

Douglas L Mann

Affiliations

Soon will be listed here.

Abstract

Recent studies have suggested a potentially important role for a family of tiny regulatory RNAs, known as microRNAs (miRNAs or miRs), in the control of diverse aspects of cardiac function in health and disease. Although the field of miRNA biology is relatively new, there is emerging evidence that miRNAs may play an important role in the pathogenesis of heart failure through their ability to regulate the expression levels of genes that govern the process of adaptive and maladaptive cardiac remodeling. Here, we review the biology of miRNAs in relation to their role in modulating various aspects of the process of cardiac remodeling, as well as discuss the potential application of miRNA biology to the field of heart failure.

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References

Salter K, Acharya C, Walters K, Redman R, Anguiano A, Garman K . An integrated approach to the prediction of chemotherapeutic response in patients with breast cancer. PLoS One. 2008; 3(4):e1908. PMC: 2270912. DOI: 10.1371/journal.pone.0001908. View

Nass R, Aiba T, Tomaselli G, Akar F . Mechanisms of disease: ion channel remodeling in the failing ventricle. Nat Clin Pract Cardiovasc Med. 2008; 5(4):196-207. DOI: 10.1038/ncpcardio1130. View

Gregory P, Bert A, Paterson E, Barry S, Tsykin A, Farshid G . The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol. 2008; 10(5):593-601. DOI: 10.1038/ncb1722. View

Luo X, Lin H, Pan Z, Xiao J, Zhang Y, Lu Y . Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. J Biol Chem. 2008; 283(29):20045-52. DOI: 10.1074/jbc.M801035200. View

Wang S, Aurora A, Johnson B, Qi X, McAnally J, Hill J . The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008; 15(2):261-71. PMC: 2685763. DOI: 10.1016/j.devcel.2008.07.002. View

Fish J, Santoro M, Morton S, Yu S, Yeh R, Wythe J . miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008; 15(2):272-84. PMC: 2604134. DOI: 10.1016/j.devcel.2008.07.008. View

Urbich C, Kuehbacher A, Dimmeler S . Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res. 2008; 79(4):581-8. DOI: 10.1093/cvr/cvn156. View

Van Rooij E, Sutherland L, Thatcher J, DiMaio J, Naseem R, Marshall W . Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A. 2008; 105(35):13027-32. PMC: 2529064. DOI: 10.1073/pnas.0805038105. View

Dash R, Kadambi V, Schmidt A, Tepe N, Biniakiewicz D, Gerst M . Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality. Circulation. 2001; 103(6):889-96. DOI: 10.1161/01.cir.103.6.889. View

10.

Samie F, Berenfeld O, Anumonwo J, Mironov S, Udassi S, Beaumont J . Rectification of the background potassium current: a determinant of rotor dynamics in ventricular fibrillation. Circ Res. 2001; 89(12):1216-23. DOI: 10.1161/hh2401.100818. View

11.

Accili E, Proenza C, Baruscotti M, DiFrancesco D . From funny current to HCN channels: 20 years of excitation. News Physiol Sci. 2002; 17:32-7. DOI: 10.1152/physiologyonline.2002.17.1.32. View

12.

Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T . Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002; 12(9):735-9. DOI: 10.1016/s0960-9822(02)00809-6. View

13.

de Boer R, Pinto Y, Van Veldhuisen D . The imbalance between oxygen demand and supply as a potential mechanism in the pathophysiology of heart failure: the role of microvascular growth and abnormalities. Microcirculation. 2003; 10(2):113-26. DOI: 10.1038/sj.mn.7800188. View

14.

Bartel D . MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116(2):281-97. DOI: 10.1016/s0092-8674(04)00045-5. View

15.

Urabe Y, Hamada Y, Spinale F, Carabello B, Kent R, Cooper 4th G . Cardiocyte contractile performance in experimental biventricular volume-overload hypertrophy. Am J Physiol. 1993; 264(5 Pt 2):H1615-23. DOI: 10.1152/ajpheart.1993.264.5.H1615. View

16.

Nakao K, Minobe W, Roden R, Bristow M, Leinwand L . Myosin heavy chain gene expression in human heart failure. J Clin Invest. 1997; 100(9):2362-70. PMC: 508434. DOI: 10.1172/JCI119776. View

17.

Anand I, Liu D, Chugh S, Prahash A, Gupta S, John R . Isolated myocyte contractile function is normal in postinfarct remodeled rat heart with systolic dysfunction. Circulation. 1997; 96(11):3974-84. DOI: 10.1161/01.cir.96.11.3974. View

18.

Carmeliet P, Ng Y, Nuyens D, Theilmeier G, Brusselmans K, Cornelissen I . Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat Med. 1999; 5(5):495-502. DOI: 10.1038/8379. View

19.

Zicha S, Fernandez-Velasco M, Lonardo G, LHeureux N, Nattel S . Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model. Cardiovasc Res. 2005; 66(3):472-81. DOI: 10.1016/j.cardiores.2005.02.011. View

20.

Zhang H, Garratt C, Zhu J, Holden A . Role of up-regulation of IK1 in action potential shortening associated with atrial fibrillation in humans. Cardiovasc Res. 2005; 66(3):493-502. DOI: 10.1016/j.cardiores.2005.01.020. View