"Small Stem Cells" in Adult Tissues: Very Small Embryonic-like Stem Cells Stand Up!

Overview

Journal Cytometry A

Specialties Cell Biology
Radiology

Date 2008 Nov 7

PMID 18988270

Citations 38

Authors

Ewa K Zuba-Surma

Magdalena Kucia

Janina Ratajczak

Mariusz Z Ratajczak

Affiliations

Soon will be listed here.

Abstract

This review summarizes information regarding the rare population of very small embryonic-like stem cells (VSELs) that has been identified in adult tissues, emphasizing both their unique morphological features and potential biological significance. We focus on their pluripotent nature and expression of markers characteristic for embryonic stem cells (ESCs), epiblast (EP)SCs, and primordial germ cells (PGCs). Furthermore, we will discuss their rank in the developmental hierarchy of the SC compartment as well as their relationship to other bone marrow-derived, primitive, nonhematopoietic SCs including: (i) endothelial progenitor cells (EPCs); (ii) mesenchymal (M)SCs; (iii) multipotent adult progenitor cells (MAPCs); (iv) marrow-isolated adult multilineage inducible (MIAMIs) cells; (v) multipotent adult (MA)SCs; and (vi) OmniCytes. We will also present different populations of very "small SCs" that have been recently described in the literature (e.g., spore-like cells and Lin(-)/ALDH(high) long-term repopulating hematopoietic SCs).

Citing Articles

The "Mystery Cell Population" Residing in Murine Bone Marrow - A Missing Link Between Very Small Embryonic Like Stem Cells and Hematopoietic Stem Cells?.

Bujko K, Suszynska M, Franczak S, Kucia M, Ratajczak M, Ratajczak J Stem Cell Rev Rep. 2023; 19(7):2292-2298.

PMID: 37386334 PMC: 10579127. DOI: 10.1007/s12015-023-10581-7.

Alteration in Expression of Primordial Germ Cell (PGC) Markers During Induction of Human Amniotic Mesenchymal Stem Cells (hAMSCs).

Alifi F, Asgari H J Reprod Infertil. 2020; 21(1):59-64.

PMID: 32175266 PMC: 7048695.

Mouse Pancreas Stem/Progenitor Cells Get Augmented by Streptozotocin and Regenerate Diabetic Pancreas After Partial Pancreatectomy.

Mohammad S, Metkari S, Bhartiya D Stem Cell Rev Rep. 2019; 16(1):144-158.

PMID: 31705263 DOI: 10.1007/s12015-019-09919-x.

Characterization and Isolation of Very Small Embryonic-like (VSEL) Stem Cells Obtained from Various Human Hematopoietic Cell Sources.

Kuruca S, Celik D, Ozerkan D, Erdemir G Stem Cell Rev Rep. 2019; 15(5):730-742.

PMID: 31172457 DOI: 10.1007/s12015-019-09896-1.

Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation.

Scarpone M, Kuebler D, Chambers A, De Filippo C, Amatuzio M, Ichim T J Transl Med. 2019; 17(1):10.

PMID: 30611285 PMC: 6321705. DOI: 10.1186/s12967-018-1750-x.

References

Murry C, Soonpaa M, Reinecke H, Nakajima H, Nakajima H, Rubart M . Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature. 2004; 428(6983):664-8. DOI: 10.1038/nature02446. View

George T, Basiji D, Hall B, Lynch D, Ortyn W, Perry D . Distinguishing modes of cell death using the ImageStream multispectral imaging flow cytometer. Cytometry A. 2004; 59(2):237-45. DOI: 10.1002/cyto.a.20048. View

DIppolito G, Diabira S, Howard G, Menei P, Roos B, Schiller P . Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential. J Cell Sci. 2004; 117(Pt 14):2971-81. DOI: 10.1242/jcs.01103. View

Martin G . Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A. 1981; 78(12):7634-8. PMC: 349323. DOI: 10.1073/pnas.78.12.7634. View

Bradley A, Evans M, Kaufman M, Robertson E . Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature. 1984; 309(5965):255-6. DOI: 10.1038/309255a0. View

Matsuoka T, Tavassoli M . Electron microscopic identification of hemopoietic progenitor cells by exploiting their sugar-recognizing receptors using a newly developed minibead technique. Exp Hematol. 1989; 17(4):326-9. View

Jones R, Wagner J, Celano P, Zicha M, Sharkis S . Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells. Nature. 1990; 347(6289):188-9. DOI: 10.1038/347188a0. View

Jones R, Collector M, Barber J, Vala M, Fackler M, May W . Characterization of mouse lymphohematopoietic stem cells lacking spleen colony-forming activity. Blood. 1996; 88(2):487-91. View

Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T . Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997; 275(5302):964-7. DOI: 10.1126/science.275.5302.964. View

10.

RADLEY J, Ellis S, Palatsides M, Williams B, Bertoncello I . Ultrastructure of primitive hematopoietic stem cells isolated using probes of functional status. Exp Hematol. 1999; 27(2):365-9. DOI: 10.1016/s0301-472x(98)00017-4. View

11.

Lanzkron S, Collector M, Sharkis S . Hematopoietic stem cell tracking in vivo: a comparison of short-term and long-term repopulating cells. Blood. 1999; 93(6):1916-21. View

12.

Pittenger M, Mackay A, Beck S, Jaiswal R, Douglas R, Mosca J . Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284(5411):143-7. DOI: 10.1126/science.284.5411.143. View

13.

Petersen B, BOWEN W, Patrene K, Mars W, Sullivan A, Murase N . Bone marrow as a potential source of hepatic oval cells. Science. 1999; 284(5417):1168-70. DOI: 10.1126/science.284.5417.1168. View

14.

Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M . Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res. 1999; 85(3):221-8. DOI: 10.1161/01.res.85.3.221. View

15.

Wojakowski W, Tendera M, Michalowska A, Majka M, Kucia M, Maslankiewicz K . Mobilization of CD34/CXCR4+, CD34/CD117+, c-met+ stem cells, and mononuclear cells expressing early cardiac, muscle, and endothelial markers into peripheral blood in patients with acute myocardial infarction. Circulation. 2004; 110(20):3213-20. DOI: 10.1161/01.CIR.0000147609.39780.02. View

16.

Kanatsu-Shinohara M, Inoue K, Lee J, Yoshimoto M, Ogonuki N, Miki H . Generation of pluripotent stem cells from neonatal mouse testis. Cell. 2004; 119(7):1001-12. DOI: 10.1016/j.cell.2004.11.011. View

17.

Kucia M, Ratajczak J, Ratajczak M . Bone marrow as a source of circulating CXCR4+ tissue-committed stem cells. Biol Cell. 2005; 97(2):133-46. DOI: 10.1042/BC20040069. View

18.

Godin I, Cumano A . Of birds and mice: hematopoietic stem cell development. Int J Dev Biol. 2005; 49(2-3):251-7. DOI: 10.1387/ijdb.041945ig. View

19.

Zuba-Surma E, Kucia M, Abdel-Latif A, Dawn B, Hall B, Singh R . Morphological characterization of very small embryonic-like stem cells (VSELs) by ImageStream system analysis. J Cell Mol Med. 2007; 12(1):292-303. PMC: 3823490. DOI: 10.1111/j.1582-4934.2007.00154.x. View

20.

Martins A, Alves J, Trujillo C, Schwindt T, Barnabe G, Motta F . Kinin-B2 receptor expression and activity during differentiation of embryonic rat neurospheres. Cytometry A. 2008; 73(4):361-8. DOI: 10.1002/cyto.a.20519. View