Genes and Sjögren's Syndrome

Overview

Journal Rheum Dis Clin North Am

Publisher Elsevier

Specialty Rheumatology

Date 2008 Nov 6

PMID 18984408

Citations 26

Authors

Beth L Cobb

Christopher J Lessard

John B Harley

Kathy L Moser

Affiliations

Soon will be listed here.

Abstract

The evidence for a strong genetic component conferring susceptibility to primary Sjögren's syndrome (SS) is mounting. Several associations with SS have been reported and provide evidence that the HLA region harbors important susceptibility loci and that multiple genes outside the HLA region play a role. Genetic discovery lags behind success observed in related autoimmune diseases. Identifying genetic factors that cause SS will allow more precise definition of pathogenic mechanisms leading to the overall SS phenotype and clinically heterogeneous subsets of patients. Critical opportunities are certain to follow for translation into improved diagnosis and therapies for SS and its spectrum diseases.

Citing Articles

Interactions between TNFAIP3, PTPN22, and TRAF1-C5 gene polymorphisms in patients with primary Sjögren's syndrome.

Cadena-Sandoval D, Montufar-Robles I, Barbosa-Cobos R, Hernandez-Molina G, Karen Salas-Garcia A, Sanchez-Zauco N Arch Rheumatol. 2024; 39(1):60-70.

PMID: 38774701 PMC: 11104759. DOI: 10.46497/ArchRheumatol.2024.10108.

Healthcare knowledge graph construction: A systematic review of the state-of-the-art, open issues, and opportunities.

Abu-Salih B, Al-Qurishi M, Alweshah M, Al-Smadi M, Alfayez R, Saadeh H J Big Data. 2023; 10(1):81.

PMID: 37274445 PMC: 10225120. DOI: 10.1186/s40537-023-00774-9.

Sjögren Syndrome: New Insights in the Pathogenesis and Role of Nuclear Medicine.

Kelly A, Nelson R, Sara R, Alberto S J Clin Med. 2022; 11(17).

PMID: 36079157 PMC: 9456759. DOI: 10.3390/jcm11175227.

CD4+ Cytotoxic T Cells Involved in the Development of EBV-Associated Diseases.

Ruiz-Pablos M Pathogens. 2022; 11(8).

PMID: 35894054 PMC: 9330826. DOI: 10.3390/pathogens11080831.

Gene Variation at Immunomodulatory and Cell Adhesion Molecules Loci Impacts Primary Sjögren's Syndrome.

Casado-Llombart S, Gheitasi H, Arino S, Consuegra-Fernandez M, Armiger-Borras N, Kostov B Front Med (Lausanne). 2022; 9:822290.

PMID: 35372412 PMC: 8971656. DOI: 10.3389/fmed.2022.822290.

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