» Articles » PMID: 18983658

Concentrations Versus Amounts of Biomarkers in Urine: a Comparison of Approaches to Assess Pyrethroid Exposure

Overview
Journal Environ Health
Publisher Biomed Central
Date 2008 Nov 6
PMID 18983658
Citations 7
Authors
Affiliations
Soon will be listed here.
Abstract

Background: Assessment of human exposure to non-persistent pesticides such as pyrethroids is often based on urinary biomarker measurements. Urinary metabolite levels of these pesticides are usually reported in volume-weighted concentrations or creatinine-adjusted concentrations measured in spot urine samples. It is known that these units are subject to intra- and inter-individual variations. This research aimed at studying the impact of these variations on the assessment of pyrethroid absorbed doses at individual and population levels.

Methods: Using data obtained from various adult and infantile populations, the intra and inter-individual variability in the urinary flow rate and creatinine excretion rate was first estimated. Individual absorbed doses were then calculated using volume-weighted or creatinine-adjusted concentrations according to published approaches and compared to those estimated from the amounts of biomarkers excreted in 15- or 24-h urine collections, the latter serving as a benchmark unit. The effect of the units of measurements (volume-weighted or creatinine adjusted concentrations or 24-h amounts) on results of the comparison of pyrethroid biomarker levels between two populations was also evaluated.

Results: Estimation of daily absorbed doses of permethrin from volume-weighted or creatinine-adjusted concentrations of biomarkers was found to potentially lead to substantial under or overestimation when compared to doses reconstructed directly from amounts excreted in urine during a given period of time (-70 to +573% and -83 to +167%, respectively). It was also shown that the variability in creatinine excretion rate and urinary flow rate may introduce a bias in the case of between population comparisons.

Conclusion: The unit chosen to express biomonitoring data may influence the validity of estimated individual absorbed dose as well as the outcome of between population comparisons.

Citing Articles

A Novel Approach to Integrate Human Biomonitoring Data with Model Predicted Dietary Exposures: A Crop Protection Chemical Case Study Using Lambda-Cyhalothrin.

Cuvelier N, Avanasi R, Grunenwald M, Ramanarayanan T, Wolf D, Bartell S J Agric Food Chem. 2024; 72(20):11663-11671.

PMID: 38718292 PMC: 11117394. DOI: 10.1021/acs.jafc.3c07071.


Assessing Durability and Safety of Permethrin Impregnated Uniforms Used by Outdoor Workers to Prevent Tick Bites after One Year of Use.

Richards S, Driver J, Dyer M, Mather T, Funkhouser S, Mitchell C J Med Entomol. 2021; 59(2):615-622.

PMID: 34958094 PMC: 9272190. DOI: 10.1093/jme/tjab216.


Exosomal miRNAs in urine associated with children's cardiorenal parameters: a cross-sectional study.

Levin-Schwartz Y, Curtin P, Flores D, Aushev V, Tamayo-Ortiz M, Svensson K Epigenomics. 2021; 13(7):499-512.

PMID: 33635093 PMC: 8033423. DOI: 10.2217/epi-2020-0342.


Adjusting urinary chemical biomarkers for hydration status during pregnancy.

MacPherson S, Arbuckle T, Fisher M J Expo Sci Environ Epidemiol. 2018; 28(5):481-493.

PMID: 29880833 PMC: 8075920. DOI: 10.1038/s41370-018-0043-z.


Monitoring wastewater for assessing community health: Sewage Chemical-Information Mining (SCIM).

Daughton C Sci Total Environ. 2017; 619-620:748-764.

PMID: 29161600 PMC: 6091531. DOI: 10.1016/j.scitotenv.2017.11.102.


References
1.
RYAN W . Urine volume and the menstrual cycle. Fertil Steril. 1961; 12:277-81. DOI: 10.1016/s0015-0282(16)61174-3. View

2.
Neubert A, Remer T . The impact of dietary protein intake on urinary creatinine excretion in a healthy pediatric population. J Pediatr. 1998; 133(5):655-9. DOI: 10.1016/s0022-3476(98)70107-6. View

3.
Barr D, Wilder L, Caudill S, Gonzalez A, Needham L, Pirkle J . Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect. 2005; 113(2):192-200. PMC: 1277864. DOI: 10.1289/ehp.7337. View

4.
Kissel J, Curl C, Kedan G, Lu C, Griffith W, Barr D . Comparison of organophosphorus pesticide metabolite levels in single and multiple daily urine samples collected from preschool children in Washington State. J Expo Anal Environ Epidemiol. 2004; 15(2):164-71. DOI: 10.1038/sj.jea.7500384. View

5.
Meeker J, Barr D, Ryan L, Herrick R, Bennett D, Bravo R . Temporal variability of urinary levels of nonpersistent insecticides in adult men. J Expo Anal Environ Epidemiol. 2004; 15(3):271-81. DOI: 10.1038/sj.jea.7500402. View