Protein Synthesis by Platelets: Historical and New Perspectives

Overview

Journal J Thromb Haemost

Publisher Elsevier

Specialty Hematology

Date 2008 Nov 6

PMID 18983498

Citations 101

Authors

A S Weyrich

H Schwertz

L W Kraiss

G A Zimmerman

Affiliations

Soon will be listed here.

Abstract

In the late 1960s, numerous investigators independently demonstrated that platelets are capable of synthesizing proteins. Studies continued at a steady pace over the next 30 years and into the 21st century. Collectively, these investigations confirmed that platelets synthesize proteins and that the pattern of protein synthesis changes in response to cellular activation. More recent studies have characterized the mechanisms by which platelets synthesize proteins and have shown that protein synthesis alters the phenotype and functions of platelets. Here, we chronologically review our increased understanding of protein synthetic responses in platelets and discuss how the field may evolve over the next decade.

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References

Boullin D, Votavova M, Green A . Protein synthesis by human blood platelets after accumulation of leucine and arginine. Thromb Diath Haemorrh. 1972; 28(1):54-64. View

Hirsh J . Platelet age: its relationship to platelet size, function and metabolism. Br J Haematol. 1972; 23:Suppl:209-14. DOI: 10.1111/j.1365-2141.1972.tb03520.x. View

Schneider W, Lampe K, SCHEURLEN P . [Studies on protein synthesis of human blood platelets]. Verh Dtsch Ges Inn Med. 1971; 77:400-3. View

Freedman M, Karpatkin S . Requirement of iron for platelet protein synthesis. Biochem Biophys Res Commun. 1973; 54(2):475-81. DOI: 10.1016/0006-291x(73)91445-9. View

Schneider W, Dries R, Kulenkampff G . Studies on the protein and nucleic acid synthesis of normal human blood platelets. Acta Univ Carol Med Monogr. 1972; 53:113-7. View

Agam G, Bessler H, Djaldetti M . In vitro DNA and RNA synthesis by human platelets. Biochim Biophys Acta. 1976; 425(1):41-8. DOI: 10.1016/0005-2787(76)90214-8. View

Agam G, Gasner S, Bessler H, Fishman P, Djaldetti M . Chloramphenicol induced inhibition of platelet protein synthesis: in vitro and in vivo studies. Br J Haematol. 1976; 33(1):53-9. DOI: 10.1111/j.1365-2141.1976.tb00971.x. View

Bessler H, Agam G, Djaldetti M . Increased protein synthesis by human platelets during phagocytosis of latex particles in vitro. Thromb Haemost. 1976; 35(2):350-7. View

Agam G, Djaldetti M . Inhibition of human platelet mitochondrial protein synthesis by chloramphenicol. Biomedicine. 1977; 27(2):66-9. View

10.

Shaw T, Chesterman C, Morgan F . In vitro synthesis of low molecular weight proteins in human platelets: absence of labelled release products. Thromb Res. 1984; 36(6):619-31. DOI: 10.1016/0049-3848(84)90201-9. View

11.

Kieffer N, Guichard J, Farcet J, Vainchenker W, BRETON-GORIUS J . Biosynthesis of major platelet proteins in human blood platelets. Eur J Biochem. 1987; 164(1):189-95. DOI: 10.1111/j.1432-1033.1987.tb11010.x. View

12.

Bruce I, Kerry R . The effect of chloramphenicol and cycloheximide on platelet aggregation and protein synthesis. Biochem Pharmacol. 1987; 36(11):1769-73. DOI: 10.1016/0006-2952(87)90236-x. View

13.

Belloc F, Heilmann E, Combrie R, Boisseau M, Nurden A . Protein synthesis and storage in human platelets: a defective storage of fibrinogen in platelets in Glanzmann's thrombasthenia. Biochim Biophys Acta. 1987; 925(2):218-25. DOI: 10.1016/0304-4165(87)90112-7. View

14.

Friedman J, Ishay J . Inhibition of protein synthesis by an extract of the venom sac of the oriental hornet (Vespa orientalis). Toxicon. 1987; 25(6):673-6. DOI: 10.1016/0041-0101(87)90114-0. View

15.

Ludany A, Kellermayer M . Protein synthesis in human platelets. Clin Biochem. 1988; 21(2):107-10. DOI: 10.1016/s0009-9120(88)80097-3. View

16.

Newman P, Gorski J, White 2nd G, Gidwitz S, Cretney C, Aster R . Enzymatic amplification of platelet-specific messenger RNA using the polymerase chain reaction. J Clin Invest. 1988; 82(2):739-43. PMC: 303572. DOI: 10.1172/JCI113656. View

17.

Hawrylowicz C, Santoro S, Platt F, UNANUE E . Activated platelets express IL-1 activity. J Immunol. 1989; 143(12):4015-8. View

18.

Hawrylowicz C, Howells G, Feldmann M . Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production. J Exp Med. 1991; 174(4):785-90. PMC: 2118954. DOI: 10.1084/jem.174.4.785. View

19.

Kaplanski G, Porat R, Aiura K, Erban J, Gelfand J, Dinarello C . Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1-mediated event. Blood. 1993; 81(10):2492-5. View

20.

Rosenwald I, Pechet L, Han A, Lu L, Pihan G, Woda B . Expression of translation initiation factors elF-4E and elF-2alpha and a potential physiologic role of continuous protein synthesis in human platelets. Thromb Haemost. 2001; 85(1):142-51. View