Significant Influence of the Primary Liver Disease on the Outcomes of Hepatic Retransplantation

Overview

Journal Ir J Med Sci

Specialty General Medicine

Date 2008 Nov 5

PMID 18982406

Citations 1

Authors

A Qasim

B M Zaman

J Geoghegan

D Maguire

O Traynor

J Hegarty

P A McCormick

Affiliations

Soon will be listed here.

Abstract

Background: There are many indications for hepatic retransplantation.

Aim: To identify factors influencing retransplantation needs and outcomes.

Patients And Methods: Retransplantation records from January 1993 to March 2005 were analysed. Patient and disease characteristics and survival outcomes for retransplantation were compared between various groups.

Results: Totally, 286 primary and 42 hepatic retransplantations were performed. Retransplantation indications included primary sclerosing cholangitis (PSC), primary biliary cirrhosis, chronic hepatitis C (HCV), chronic active hepatitis (CAH), and alcohol-related disease. Mean follow-up post-retransplantation was 31 +/- 9 months. Actuarial patient survival at 3 months, 1 year, 3 years, 5 years, and at the end of study was 71.4, 69, 59.5, 54.7, and 50%, respectively. Early and late retransplantation had 1-year survival of 73 and 68.5%, respectively. Retransplantation need was significantly higher for PSC, HCV, and CAH.

Conclusions: Hepatic retransplantation remains a successful salvage option for transplant complications; however, its need is significantly influenced by the primary liver disease.

Citing Articles

Liver retransplantation: Timing is equally important.

Li L, Zhang Y, Xiao F, Qu W, Zhang H, Zhu Z Medicine (Baltimore). 2023; 102(37):e35165.

PMID: 37713841 PMC: 10508473. DOI: 10.1097/MD.0000000000035165.

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