Review. The Molecular Logic of Sodium-coupled Neurotransmitter Transporters

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2008 Nov 4

PMID 18977735

Citations 24

Authors

Eric Gouaux

Affiliations

Soon will be listed here.

Abstract

Synaptic transmission at chemical synapses requires the removal of neurotransmitter from extracellular spaces. At synapses in the central nervous system, this is accomplished by sodium-coupled transport proteins, integral membrane proteins that thermodynamically couple the uptake of neurotransmitter to the uptake of sodium and, in some cases, the uptake and export of additional ions. Recent X-ray crystallographic studies have revealed the architecture of the two major families of neurotransmitter transporters and, together with additional biochemical and biophysical studies, have provided insights into mechanisms of ion coupling, substrate uptake, and inhibition of transport.

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