Novel Human Rhinoviruses and Exacerbation of Asthma in Children

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2008 Nov 4

PMID 18976575

Citations 87

Authors

Nino Khetsuriani

Xiaoyan Lu

W Gerald Teague

Neely Kazerouni

Larry J Anderson

Dean D Erdman

Affiliations

Soon will be listed here.

Abstract

To determine links between human rhinoviruses (HRV) and asthma, we used data from a case-control study, March 2003-February 2004, among children with asthma. Molecular characterization identified several likely new HRVs and showed that association with asthma exacerbations was largely driven by HRV-A and a phylogenetically distinct clade of 8 strains, genogroup C.

Citing Articles

Method to Generate High-Titer Rhinovirus C Suitable for In Vitro and In Vivo Studies.

Sajjan U Methods Mol Biol. 2025; 2903:21-30.

PMID: 40016455 DOI: 10.1007/978-1-0716-4410-2_3.

Designing a multi-epitope vaccine candidate against human rhinovirus C utilizing immunoinformatics approach.

Mamun T, Ali M, Hosen M, Rahman J, Islam M, Akib M Front Immunol. 2025; 15():1364129.

PMID: 39840071 PMC: 11747413. DOI: 10.3389/fimmu.2024.1364129.

Prevalence and Phylogenetic Analysis of Rhinoviruses in Patients with Acute Respiratory Infections and Community-Acquired Pneumonia in a Referral Hospital, Tehran, Iran.

Fazl S, Hassani S, Ramezan Nia M, Nadji P, Sadr M, Nemati F Tanaffos. 2024; 23(1):30-37.

PMID: 39703452 PMC: 11655008.

Poly I:C Pre-Treatment Induced the Anti-Viral Interferon Response in Airway Epithelial Cells.

Mitlander H, Yang Z, Krammer S, Grund J, Zirlik S, Finotto S Viruses. 2023; 15(12).

PMID: 38140569 PMC: 10747011. DOI: 10.3390/v15122328.

Cluster analysis of plasma cytokines identifies two unique endotypes of children with asthma in the pediatric intensive care unit.

Cottrill K, Rad M, Ripple M, Stephenson S, Mohammad A, Tidwell M Sci Rep. 2023; 13(1):3521.

PMID: 36864187 PMC: 9978291. DOI: 10.1038/s41598-023-30679-9.

References

Winther B, Hayden F, Hendley J . Picornavirus infections in children diagnosed by RT-PCR during longitudinal surveillance with weekly sampling: Association with symptomatic illness and effect of season. J Med Virol. 2006; 78(5):644-50. DOI: 10.1002/jmv.20588. View

Lamson D, Renwick N, Kapoor V, Liu Z, Palacios G, Ju J . MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York State during 2004-2005. J Infect Dis. 2006; 194(10):1398-402. PMC: 7110122. DOI: 10.1086/508551. View

Khetsuriani N, Kazerouni N, Erdman D, Lu X, Redd S, Anderson L . Prevalence of viral respiratory tract infections in children with asthma. J Allergy Clin Immunol. 2006; 119(2):314-21. PMC: 7112359. DOI: 10.1016/j.jaci.2006.08.041. View

McErlean P, Shackelton L, Lambert S, Nissen M, Sloots T, Mackay I . Characterisation of a newly identified human rhinovirus, HRV-QPM, discovered in infants with bronchiolitis. J Clin Virol. 2007; 39(2):67-75. PMC: 7172271. DOI: 10.1016/j.jcv.2007.03.012. View

Kistler A, Avila P, Rouskin S, Wang D, Ward T, Yagi S . Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity. J Infect Dis. 2007; 196(6):817-25. PMC: 7109683. DOI: 10.1086/520816. View

Lee W, Kiesner C, Pappas T, Lee I, Grindle K, Jartti T . A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants. PLoS One. 2007; 2(10):e966. PMC: 1989136. DOI: 10.1371/journal.pone.0000966. View

Ledford R, Collett M, Pevear D . Insights into the genetic basis for natural phenotypic resistance of human rhinoviruses to pleconaril. Antiviral Res. 2005; 68(3):135-8. DOI: 10.1016/j.antiviral.2005.08.003. View

Renwick N, Schweiger B, Kapoor V, Liu Z, Villari J, Bullmann R . A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany. J Infect Dis. 2008; 196(12):1754-60. PMC: 7109967. DOI: 10.1086/524312. View

Jartti T, Lehtinen P, Vuorinen T, Koskenvuo M, Ruuskanen O . Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children. J Med Virol. 2004; 72(4):695-9. DOI: 10.1002/jmv.20027. View

10.

Ledford R, Patel N, Demenczuk T, Watanyar A, Herbertz T, Collett M . VP1 sequencing of all human rhinovirus serotypes: insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds. J Virol. 2004; 78(7):3663-74. PMC: 371056. DOI: 10.1128/jvi.78.7.3663-3674.2004. View

11.

Andries K, Dewindt B, Snoeks J, Wouters L, Moereels H, Lewi P . Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity. J Virol. 1990; 64(3):1117-23. PMC: 249225. DOI: 10.1128/JVI.64.3.1117-1123.1990. View

12.

Gern J, Busse W . Association of rhinovirus infections with asthma. Clin Microbiol Rev. 1999; 12(1):9-18. PMC: 88904. DOI: 10.1128/CMR.12.1.9. View

13.

Laine P, Savolainen C, Blomqvist S, Hovi T . Phylogenetic analysis of human rhinovirus capsid protein VP1 and 2A protease coding sequences confirms shared genus-like relationships with human enteroviruses. J Gen Virol. 2005; 86(Pt 3):697-706. DOI: 10.1099/vir.0.80445-0. View

14.

Lau S, Yip C, Tsoi H, Lee R, So L, Lau Y . Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children. J Clin Microbiol. 2007; 45(11):3655-64. PMC: 2168475. DOI: 10.1128/JCM.01254-07. View