Evolution of Proviral Gp120 over the First Year of HIV-1 Subtype C Infection

Overview

Journal Virology

Specialty Microbiology

Date 2008 Nov 1

PMID 18973914

Citations 28

Authors

Vladimir Novitsky

Stephen Lagakos

Michaela Herzig

Caitlin Bonney

Lemme Kebaabetswe

Raabya Rossenkhan

David Nkwe

Lauren Margolin

Rosemary Musonda

Sikhulile Moyo

Elias Woldegabriel

Erik Van Widenfelt

Joseph Makhema

M Essex

Affiliations

Soon will be listed here.

Abstract

The evolution of proviral gp120 during the first year after seroconversion in HIV-1 subtype C infection was addressed in a case series of eight subjects. Multiple viral variants were found in two out of eight cases. Slow rate of viral RNA decline and high early viral RNA set point were associated with a higher level of proviral diversity from 0 to 200 days after seroconversion. Proviral divergence from MRCA over the same period also differed between subjects with slow and fast decline of viral RNA, suggesting that evolution of proviral gp120 early in infection may be linked to the level of viral RNA replication. Changes in the length of variable loops were minimal, and length reduction was more common than length increase. Potential N-linked glycosylation sites ranged +/-one site, showing common fluctuations in the V4 and V5 loops. These results highlight the role of proviral gp120 diversity and diversification in the pathogenesis of acute HIV-1 subtype C infection.

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