Cytokine Regulation of Tight Junctions

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2008 Oct 28

PMID 18952050

Citations 321

Authors

Christopher T Capaldo

Asma Nusrat

Affiliations

Soon will be listed here.

Abstract

Epithelial and endothelial tight junctions act as a rate-limiting barrier between an organism and its environment. Continuing studies have highlighted the regulation of the tight junction barrier by cytokines. Elucidation of this interplay is vital for both the understanding of physiological tight junction regulation and the etiology of pathological conditions. This review will focus on recent advances in our understanding of the molecular mechanisms of tight junctions modulation by cytokines.

Citing Articles

Recent advances in nanotherapeutics for HIV-associated neurocognitive disorders and substance use disorders.

Lomas C, Dubey R, Perez-Alvarez G, Lopez Hernandez Y, Atmar A, Arias A Nanomedicine (Lond). 2025; 20(6):603-619.

PMID: 39963928 PMC: 11902879. DOI: 10.1080/17435889.2025.2461984.

An ingestible bioimpedance sensing device for wireless monitoring of epithelial barriers.

Holt B, Stine J, Beardslee L, Ayansola H, Jin Y, Pasricha P Microsyst Nanoeng. 2025; 11(1):24.

PMID: 39915452 PMC: 11802857. DOI: 10.1038/s41378-025-00877-8.

Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids.

Sridhar A, Bakke I, Gopalakrishnan S, Osoble N, Hammarqvist E, Pettersen H Sci Rep. 2025; 15(1):3753.

PMID: 39885201 PMC: 11782514. DOI: 10.1038/s41598-025-86314-2.

The Potential Proallergenic Activity of and in vitro Studies.

Sztandera-Tymoczek M, Wdowiak-Wrobel S, Swiderska U, Palusinska-Szysz M, Szuster-Ciesielska A J Inflamm Res. 2025; 18:1107-1125.

PMID: 39881795 PMC: 11777704. DOI: 10.2147/JIR.S497219.

Soluble Herpes Virus Entry Mediator and Type II/III Interferons Are Upregulated in Primary Biliary Cholangitis.

Chung Y, Tsou H, Heneghan M, Chokshi S, Riva A Int J Mol Sci. 2025; 26(2.

PMID: 39859319 PMC: 11765339. DOI: 10.3390/ijms26020605.

References

van Deventer S . Anti-TNF antibody treatment of Crohn's disease. Ann Rheum Dis. 1999; 58 Suppl 1:I114-20. PMC: 1766571. DOI: 10.1136/ard.58.2008.i114. View

Feng J, Ito M, Ichikawa K, Isaka N, Nishikawa M, Hartshorne D . Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J Biol Chem. 1999; 274(52):37385-90. DOI: 10.1074/jbc.274.52.37385. View

Joberty G, Petersen C, Gao L, Macara I . The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2000; 2(8):531-9. DOI: 10.1038/35019573. View

Ma T, Hoa N, Tran D, Bui V, Pedram A, Mills S . Cytochalasin B modulation of Caco-2 tight junction barrier: role of myosin light chain kinase. Am J Physiol Gastrointest Liver Physiol. 2000; 279(5):G875-85. DOI: 10.1152/ajpgi.2000.279.5.G875. View

Saitou M, Furuse M, Sasaki H, Schulzke J, Fromm M, Takano H . Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell. 2000; 11(12):4131-42. PMC: 15062. DOI: 10.1091/mbc.11.12.4131. View

Duffy H, John G, Lee S, Brosnan C, Spray D . Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1beta in primary human fetal astrocytes. J Neurosci. 2000; 20(23):RC114. PMC: 6773083. View

Oshima T, Laroux F, Coe L, Morise Z, Kawachi S, Bauer P . Interferon-gamma and interleukin-10 reciprocally regulate endothelial junction integrity and barrier function. Microvasc Res. 2001; 61(1):130-43. DOI: 10.1006/mvre.2000.2288. View

Furuse M, Furuse K, Sasaki H, Tsukita S . Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol. 2001; 153(2):263-72. PMC: 2169456. DOI: 10.1083/jcb.153.2.263. View

Madara J, Stafford J . Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest. 1989; 83(2):724-7. PMC: 303735. DOI: 10.1172/JCI113938. View

10.

Katz K, Hollander D, Vadheim C, McElree C, Delahunty T, Dadufalza V . Intestinal permeability in patients with Crohn's disease and their healthy relatives. Gastroenterology. 1989; 97(4):927-31. DOI: 10.1016/0016-5085(89)91499-6. View

11.

Mullin J, Snock K . Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability. Cancer Res. 1990; 50(7):2172-6. View

12.

Ligumsky M, Simon P, Karmeli F, Rachmilewitz D . Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease. Gut. 1990; 31(6):686-9. PMC: 1378497. DOI: 10.1136/gut.31.6.686. View

13.

Broide D, Lotz M, Cuomo A, Coburn D, Federman E, Wasserman S . Cytokines in symptomatic asthma airways. J Allergy Clin Immunol. 1992; 89(5):958-67. DOI: 10.1016/0091-6749(92)90218-q. View

14.

Nakamura M, Saito H, Kasanuki J, Tamura Y, Yoshida S . Cytokine production in patients with inflammatory bowel disease. Gut. 1992; 33(7):933-7. PMC: 1379407. DOI: 10.1136/gut.33.7.933. View

15.

Adams R, Planchon S, Roche J . IFN-gamma modulation of epithelial barrier function. Time course, reversibility, and site of cytokine binding. J Immunol. 1993; 150(6):2356-63. View

16.

Goldblum S, Ding X . TNF-alpha induces endothelial cell F-actin depolymerization, new actin synthesis, and barrier dysfunction. Am J Physiol. 1993; 264(4 Pt 1):C894-905. DOI: 10.1152/ajpcell.1993.264.4.C894. View

17.

Sadlack B, Merz H, Schorle H, Schimpl A, Feller A, Horak I . Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 1993; 75(2):253-61. DOI: 10.1016/0092-8674(93)80067-o. View

18.

Marano C, Laughlin K, Russo L, Soler A, Mullin J . Long-term effects of tumor necrosis factor on LLC-PK1 transepithelial resistance. J Cell Physiol. 1993; 157(3):519-27. DOI: 10.1002/jcp.1041570311. View

19.

Nusrat A, Parkos C, Bacarra A, Godowski P, Rosen E, Madara J . Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and.... J Clin Invest. 1994; 93(5):2056-65. PMC: 294323. DOI: 10.1172/JCI117200. View

20.

STEVENSON B, Begg D . Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells. J Cell Sci. 1994; 107 ( Pt 3):367-75. DOI: 10.1242/jcs.107.3.367. View