E-I Balance and Human Diseases - from Molecules to Networking

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2008 Oct 24

PMID 18946535

Citations 88

Authors

Sabrina A Eichler

Jochen C Meier

Affiliations

Soon will be listed here.

Abstract

Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (E-I) balance, and it reviews examples of deregulation of inhibitory and excitatory systems at a molecular, network and disease level of investigation.

Citing Articles

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References

Borgdorff A, Choquet D . Regulation of AMPA receptor lateral movements. Nature. 2002; 417(6889):649-53. DOI: 10.1038/nature00780. View

Kullmann D . The neuronal channelopathies. Brain. 2002; 125(Pt 6):1177-95. DOI: 10.1093/brain/awf130. View

Hartmann M, Heumann R, Lessmann V . Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses. EMBO J. 2001; 20(21):5887-97. PMC: 125691. DOI: 10.1093/emboj/20.21.5887. View

Applegarth D, Toone J . Nonketotic hyperglycinemia (glycine encephalopathy): laboratory diagnosis. Mol Genet Metab. 2001; 74(1-2):139-46. DOI: 10.1006/mgme.2001.3224. View

Smith S . Pre-menstrual steroids. Cell Mol Life Sci. 2001; 58(9):1263-75. PMC: 11337407. DOI: 10.1007/PL00000938. View

Legendre P . The glycinergic inhibitory synapse. Cell Mol Life Sci. 2001; 58(5-6):760-93. PMC: 11337367. DOI: 10.1007/pl00000899. View

Graf E, Zhang X, Jin S, Linhoff M, Craig A . Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell. 2004; 119(7):1013-26. PMC: 2826211. DOI: 10.1016/j.cell.2004.11.035. View

Zhang L, Gong N, Fei D, Xu L, Xu T . Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology. 2007; 33(3):701-11. DOI: 10.1038/sj.npp.1301449. View

Lau C, Zukin R . NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat Rev Neurosci. 2007; 8(6):413-26. DOI: 10.1038/nrn2153. View

10.

Ehlers M, Heine M, Groc L, Lee M, Choquet D . Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity. Neuron. 2007; 54(3):447-60. PMC: 1993808. DOI: 10.1016/j.neuron.2007.04.010. View

11.

Lardi-Studler B, Smolinsky B, Petitjean C, Koenig F, Sidler C, Meier J . Vertebrate-specific sequences in the gephyrin E-domain regulate cytosolic aggregation and postsynaptic clustering. J Cell Sci. 2007; 120(Pt 8):1371-82. DOI: 10.1242/jcs.003905. View

12.

Stief F, Zuschratter W, Hartmann K, Schmitz D, Draguhn A . Enhanced synaptic excitation-inhibition ratio in hippocampal interneurons of rats with temporal lobe epilepsy. Eur J Neurosci. 2007; 25(2):519-28. DOI: 10.1111/j.1460-9568.2006.05296.x. View

13.

Wake H, Watanabe M, Moorhouse A, Kanematsu T, Horibe S, Matsukawa N . Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation. J Neurosci. 2007; 27(7):1642-50. PMC: 6673731. DOI: 10.1523/JNEUROSCI.3104-06.2007. View

14.

Craig A, Kang Y . Neurexin-neuroligin signaling in synapse development. Curr Opin Neurobiol. 2007; 17(1):43-52. PMC: 2820508. DOI: 10.1016/j.conb.2007.01.011. View

15.

M Durand C, Betancur C, Boeckers T, Bockmann J, Chaste P, Fauchereau F . Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat Genet. 2006; 39(1):25-7. PMC: 2082049. DOI: 10.1038/ng1933. View

16.

Feng J, Schroer R, Yan J, Song W, Yang C, Bockholt A . High frequency of neurexin 1beta signal peptide structural variants in patients with autism. Neurosci Lett. 2006; 409(1):10-3. DOI: 10.1016/j.neulet.2006.08.017. View

17.

Bogdanov Y, Michels G, Armstrong-Gold C, Haydon P, Lindstrom J, Pangalos M . Synaptic GABAA receptors are directly recruited from their extrasynaptic counterparts. EMBO J. 2006; 25(18):4381-9. PMC: 1570424. DOI: 10.1038/sj.emboj.7601309. View

18.

Varoqueaux F, Jamain S, Brose N . Neuroligin 2 is exclusively localized to inhibitory synapses. Eur J Cell Biol. 2004; 83(9):449-56. DOI: 10.1078/0171-9335-00410. View

19.

Mohn A, Gainetdinov R, Caron M, Koller B . Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell. 1999; 98(4):427-36. DOI: 10.1016/s0092-8674(00)81972-8. View

20.

Herzog A . Progesterone therapy in women with epilepsy: a 3-year follow-up. Neurology. 1999; 52(9):1917-8. DOI: 10.1212/wnl.52.9.1917-a. View