Longitudinal Associations Between Alcohol Problems and Depressive Symptoms: Early Adolescence Through Early Adulthood

Overview

Journal Alcohol Clin Exp Res

Specialty Psychiatry

Date 2008 Oct 24

PMID 18945223

Citations 102

Authors

Naomi R Marmorstein

Affiliations

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Abstract

Background: Alcohol use-related problems and depressive symptoms are clearly associated with each other, but results regarding the nature of this association have been inconsistent. In addition, the possible moderating effects of age and gender have not been comprehensively examined. The goals of this study were to clarify: (i) how depressive symptoms affect the levels and trajectory of alcohol use-related problems, (ii) how alcohol use-related problems affect the levels and trajectory of depressive symptoms, and (iii) whether there are differences in these associations at different points in development or between males and females.

Methods: Participants for this study were drawn from the National Longitudinal Study of Adolescent Health (AddHealth) data set, a community-based sample of 20,728 adolescents followed from adolescence through early adulthood. Multilevel models were used to assess how each problem affected the level and rate of change in the other problem over time; gender was considered as a possible moderator of these associations.

Results: The results indicated that alcohol use-related problems and depressive symptoms had reciprocal, positive associations with each other during the period from early adolescence through early adulthood; however, these effects differed somewhat by gender and age. High levels of depressive symptoms were associated with higher initial levels of alcohol problems (particularly among females), as well as faster increases in alcohol problems over time among males. High levels of alcohol problems were associated with higher initial levels of depressive symptoms (particularly among females), as well as less curvature in the slope of depressive symptoms so that although there was a large difference between people with high and low depressive symptoms in early adolescence, by early adulthood the difference was smaller (particularly among females).

Conclusions: These results highlight the importance of examining gender and age in studies on the associations between affective disorders and substance use disorders.

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References

Bovasso G . Cannabis abuse as a risk factor for depressive symptoms. Am J Psychiatry. 2001; 158(12):2033-7. DOI: 10.1176/appi.ajp.158.12.2033. View

White H, Xie M, Thompson W, Loeber R, Stouthamer-Loeber M . Psychopathology as a predictor of adolescent drug use trajectories. Psychol Addict Behav. 2001; 15(3):210-8. View

Fu Q, Heath A, Bucholz K, Nelson E, Goldberg J, Lyons M . Shared genetic risk of major depression, alcohol dependence, and marijuana dependence: contribution of antisocial personality disorder in men. Arch Gen Psychiatry. 2002; 59(12):1125-32. DOI: 10.1001/archpsyc.59.12.1125. View

Clark D, De Bellis M, Lynch K, Cornelius J, Martin C . Physical and sexual abuse, depression and alcohol use disorders in adolescents: onsets and outcomes. Drug Alcohol Depend. 2003; 69(1):51-60. DOI: 10.1016/s0376-8716(02)00254-5. View

Marmorstein N, Iacono W . Major depression and conduct disorder in a twin sample: gender, functioning, and risk for future psychopathology. J Am Acad Child Adolesc Psychiatry. 2003; 42(2):225-33. DOI: 10.1097/00004583-200302000-00017. View

Kessler R . Epidemiology of women and depression. J Affect Disord. 2003; 74(1):5-13. DOI: 10.1016/s0165-0327(02)00426-3. View

Nurnberger Jr J, Foroud T, Flury L, Meyer E, Wiegand R . Is there a genetic relationship between alcoholism and depression?. Alcohol Res Health. 2003; 26(3):233-40. PMC: 6683839. View

Costello E, Mustillo S, Erkanli A, Keeler G, Angold A . Prevalence and development of psychiatric disorders in childhood and adolescence. Arch Gen Psychiatry. 2003; 60(8):837-44. DOI: 10.1001/archpsyc.60.8.837. View

Hettema J, Prescott C, Kendler K . The effects of anxiety, substance use and conduct disorders on risk of major depressive disorder. Psychol Med. 2003; 33(8):1423-32. DOI: 10.1017/s0033291703008365. View

10.

Stice E, Burton E, Shaw H . Prospective relations between bulimic pathology, depression, and substance abuse: unpacking comorbidity in adolescent girls. J Consult Clin Psychol. 2004; 72(1):62-71. PMC: 1237030. DOI: 10.1037/0022-006X.72.1.62. View

11.

Zucker R . The four alcoholisms: a developmental account of the etiologic process. Nebr Symp Motiv. 1986; 34:27-83. View

12.

Deykin E, Buka S, Zeena T . Depressive illness among chemically dependent adolescents. Am J Psychiatry. 1992; 149(10):1341-7. DOI: 10.1176/ajp.149.10.1341. View

13.

Bukstein O, GLANCY L, Kaminer Y . Patterns of affective comorbidity in a clinical population of dually diagnosed adolescent substance abusers. J Am Acad Child Adolesc Psychiatry. 1992; 31(6):1041-5. DOI: 10.1097/00004583-199211000-00007. View

14.

Kendler K, Heath A, Neale M, Kessler R, Eaves L . Alcoholism and major depression in women. A twin study of the causes of comorbidity. Arch Gen Psychiatry. 1993; 50(9):690-8. DOI: 10.1001/archpsyc.1993.01820210024003. View

15.

Kessler R, McGonagle K, Zhao S, Nelson C, Hughes M, Eshleman S . Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994; 51(1):8-19. DOI: 10.1001/archpsyc.1994.03950010008002. View

16.

Henry B, Feehan M, McGee R, Stanton W, Moffitt T, Silva P . The importance of conduct problems and depressive symptoms in predicting adolescent substance use. J Abnorm Child Psychol. 1993; 21(5):469-80. DOI: 10.1007/BF00916314. View

17.

Clark D, Pollock N, Bukstein O, Mezzich A, Bromberger J, Donovan J . Gender and comorbid psychopathology in adolescents with alcohol dependence. J Am Acad Child Adolesc Psychiatry. 1997; 36(9):1195-203. DOI: 10.1097/00004583-199709000-00011. View

18.

Hankin B, Abramson L, Moffitt T, Silva P, McGee R, Angell K . Development of depression from preadolescence to young adulthood: emerging gender differences in a 10-year longitudinal study. J Abnorm Psychol. 1998; 107(1):128-40. DOI: 10.1037//0021-843x.107.1.128. View

19.

Clark D, Kirisci L, Tarter R . Adolescent versus adult onset and the development of substance use disorders in males. Drug Alcohol Depend. 1998; 49(2):115-21. DOI: 10.1016/s0376-8716(97)00154-3. View

20.

Prescott C, McArdle J, Hishinuma E, Johnson R, Miyamoto R, Andrade N . Prediction of major depression and dysthymia from CES-D scores among ethnic minority adolescents. J Am Acad Child Adolesc Psychiatry. 1998; 37(5):495-503. DOI: 10.1097/00004583-199805000-00012. View