Stereological Evaluation of Volumetric Asymmetry in Healthy Human Cerebellum

Overview

Journal Surg Radiol Anat

Specialties Anatomy & Histology
General Surgery
Radiology

Date 2008 Oct 23

PMID 18941706

Citations 5

Authors

Nuket Gocmen-Mas

Can Pelin

Sinan Canan

Ayse Canan Yazici

Ragiba Zagyapan

Sevda Senan

Hamit Selim Karabekir

Bunyamin Sahin

Affiliations

Soon will be listed here.

Abstract

Objectives: Age-related volumetric differences in brain anatomy or volumetric brain analyses in many disorders are of interest. Delineating the normal anatomical cerebellar volume is of importance for both the anatomists and clinicians. In the present study, we aimed to evaluate the cerebellar volume using a stereological technique and to determine the possible volumetric asymmetry depending on age and gender.

Materials And Methods: Volumetric asymmetry of cerebellar hemispheres was evaluated using stereological method on the magnetic resonance images (MRI) of healthy male and female subjects. Randomly selected individuals (27 males, 27 females) aged between 10-86 years who have normal brain MRI were enclosed in the study. All the subjects were right handed. The individuals were divided into three groups according to age as 18-34 (young), 35-60 (middle aged) and 60-84 (elder) and their MRI images were analyzed. The data set were analyzed by two factor repeated measure analysis.

Results: Although the cerebellum was smaller between young and middle aged groups and also middle aged and elder groups, there were no any statistically significant differences between compared groups' mean (P > 0.05). There were not statistically differences according to sex and age groups (P > 0.05).

Conclusions: There was no cerebellar asymmetry between compared groups. The stereological evaluation of cerebellar asymmetry in humans correlate with both gender and age groups is of importance for both clinicians and anatomists. The technique is simple, reliable, unbiased and inexpensive.

Citing Articles

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Isiklar S, Demir I, Ozdemir S, Ozpar R Brain Topogr. 2023; 36(6):901-925.

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Delineation of Subregions in the Early Postnatal Human Cerebellum for Design-Based Stereologic Studies.

Fichtl A, Buttner A, Hof P, Schmitz C, Kiessling M Front Neuroanat. 2018; 11:134.

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Comparison of two methods for the estimation of subcortical volume and asymmetry using magnetic resonance imaging: a methodological study.

Ertekin T, Acer N, Icer S, Ilica A Surg Radiol Anat. 2012; 35(4):301-9.

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Evaluation of cerebellar and cerebral volume in migraine with aura: a stereological study.

Yilmaz-Kusbeci O, Gocmen-Mas N, Yucel A, Karabekir H, Ertekin T, Yazici A Cerebellum. 2010; 9(3):345-51.

PMID: 20352394 DOI: 10.1007/s12311-010-0167-8.

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