Gene Expression Profiling of Blood to Predict the Onset of Leukemia

Overview

Journal Blood Cells Mol Dis

Specialty Hematology

Date 2008 Oct 22

PMID 18938091

Citations 2

Authors

Mario Medvedovic

Danielle Halbleib

Marian L Miller

Kathy LaDow

Maureen A Sartor

Craig R Tomlinson

Affiliations

Soon will be listed here.

Abstract

No studies have tested the hypothesis that the onset of a disease can be predicted by gene expression profiling. The AKR/J mouse strain, which spontaneously develops acute T cell lymphatic leukemia, was used to implement a novel strategy to generate global gene expression profiles of WBCs at different time points. The experimental approach was bias free because it was unknown as to which individuals in the mouse population would eventually develop the disease. Our results suggest that profiling WBC gene expression may be an effective means for the very early diagnosis of disease in humans.

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