Antiarrhythmic Benefits of Targeting the Na+/Ca2+ Exchanger

Overview

Journal Heart Rhythm

Publisher Elsevier

Specialty Cardiology & Vascular Diseases

Date 2008 Oct 22

PMID 18929334

Citations 1

Authors

Justus Anumonwo

Affiliations

Soon will be listed here.

Citing Articles

Cardiac strong inward rectifier potassium channels.

Anumonwo J, Lopatin A J Mol Cell Cardiol. 2009; 48(1):45-54.

PMID: 19703462 PMC: 2813336. DOI: 10.1016/j.yjmcc.2009.08.013.

References

Tomaselli G, Marban E . Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res. 1999; 42(2):270-83. DOI: 10.1016/s0008-6363(99)00017-6. View

Milberg P, Pott C, Fink M, Frommeyer G, Matsuda T, Baba A . Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3. Heart Rhythm. 2008; 5(10):1444-52. DOI: 10.1016/j.hrthm.2008.06.017. View

Volders P, Vos M, Szabo B, Sipido K, de Groot S, Gorgels A . Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts. Cardiovasc Res. 2000; 46(3):376-92. DOI: 10.1016/s0008-6363(00)00022-5. View

Bers D . Calcium fluxes involved in control of cardiac myocyte contraction. Circ Res. 2000; 87(4):275-81. DOI: 10.1161/01.res.87.4.275. View

Bednar M, Harrigan E, Anziano R, Camm A, Ruskin J . The QT interval. Prog Cardiovasc Dis. 2001; 43(5 Suppl 1):1-45. DOI: 10.1053/pcad.2001.21469. View

Spencer C, Sham J . Effects of Na+/Ca2+ exchange induced by SR Ca2+ release on action potentials and afterdepolarizations in guinea pig ventricular myocytes. Am J Physiol Heart Circ Physiol. 2003; 285(6):H2552-62. DOI: 10.1152/ajpheart.00274.2003. View

Akabas M . Na+/Ca2+ exchange inhibitors: potential drugs to mitigate the severity of ischemic injury. Mol Pharmacol. 2004; 66(1):8-10. DOI: 10.1124/mol.104.000232.. View

R Shannon T, Wang F, Puglisi J, Weber C, Bers D . A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J. 2004; 87(5):3351-71. PMC: 1304803. DOI: 10.1529/biophysj.104.047449. View

Kass R, Tsien R, Weingart R . Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres. J Physiol. 1978; 281:209-26. PMC: 1282692. DOI: 10.1113/jphysiol.1978.sp012417. View

10.

Berlin J, Cannell M, Lederer W . Cellular origins of the transient inward current in cardiac myocytes. Role of fluctuations and waves of elevated intracellular calcium. Circ Res. 1989; 65(1):115-26. DOI: 10.1161/01.res.65.1.115. View

11.

Luo C, Rudy Y . A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circ Res. 1994; 74(6):1097-113. DOI: 10.1161/01.res.74.6.1097. View

12.

Benardeau A, Hatem S, Rucker-Martin C, Le Grand B, Mace L, Dervanian P . Contribution of Na+/Ca2+ exchange to action potential of human atrial myocytes. Am J Physiol. 1996; 271(3 Pt 2):H1151-61. DOI: 10.1152/ajpheart.1996.271.3.H1151. View

13.

Janvier N, Harrison S, Boyett M . The role of inward Na(+)-Ca2+ exchange current in the ferret ventricular action potential. J Physiol. 1997; 498 ( Pt 3):611-25. PMC: 1159179. DOI: 10.1113/jphysiol.1997.sp021887. View

14.

Priori S, Barhanin J, Hauer R, Haverkamp W, Jongsma H, Kleber A . Genetic and molecular basis of cardiac arrhythmias; impact on clinical management. Study group on molecular basis of arrhythmias of the working group on arrhythmias of the european society of cardiology. Eur Heart J. 1999; 20(3):174-95. DOI: 10.1053/euhj.1998.1220. View

15.

Moss A, Kass R . Long QT syndrome: from channels to cardiac arrhythmias. J Clin Invest. 2005; 115(8):2018-24. PMC: 1180552. DOI: 10.1172/JCI25537. View

16.

Antzelevitch C . Cardiac repolarization. The long and short of it. Europace. 2005; 7 Suppl 2:3-9. PMC: 1473216. DOI: 10.1016/j.eupc.2005.05.010. View

17.

Goldenberg I, Moss A . Long QT syndrome. J Am Coll Cardiol. 2008; 51(24):2291-300. DOI: 10.1016/j.jacc.2008.02.068. View