Mnesic Imbalance: a Cognitive Theory About Autism Spectrum Disorders
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Autism is characterized by impairments in social interaction, communicative capacity and behavioral flexibility. Some cognitive theories can be useful for finding a relationship between these irregularities and the biological mechanisms that may give rise to this disorder. Among such theories are mentalizing deficit, weak central coherence and executive dysfunction, but none of them has been able to explain all three diagnostic symptoms of autism. These cognitive disorders may be related among themselves by faulty learning, since several research studies have shown that the brains of autistic individuals have abnormalities in the cerebellum, which plays a role in procedural learning. In keeping with this view, one may postulate the possibility that declarative memory replaces faulty procedural memory in some of its functions, which implies making conscious efforts in order to perform actions that are normally automatic. This may disturb cognitive development, resulting in autism symptoms. Furthermore, this mnesic imbalance is probably involved in all autism spectrum disorders. In the present work, this theory is expounded, including preliminary supporting evidence.
Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test.
Zhang H, Zhou H, Lencz T, Farrer L, Kranzler H, Gelernter J Am J Med Genet B Neuropsychiatr Genet. 2018; 177(5):511-519.
PMID: 30134085 PMC: 6110090. DOI: 10.1002/ajmg.b.32642.
Vasa R, Mostofsky S, Ewen J Biol Psychiatry Cogn Neurosci Neuroimaging. 2017; 1(3):245-252.
PMID: 28083565 PMC: 5222574. DOI: 10.1016/j.bpsc.2016.02.003.
Goodman J, Marsh R, Peterson B, Packard M J Child Psychol Psychiatry. 2013; 55(6):582-610.
PMID: 24286520 PMC: 4244838. DOI: 10.1111/jcpp.12169.
Theory of Mind Deficit versus Faulty Procedural Memory in Autism Spectrum Disorders.
Romero-Munguia M Autism Res Treat. 2013; 2013:128264.
PMID: 23862063 PMC: 3687595. DOI: 10.1155/2013/128264.
The biopsychosocial processes in autism spectrum disorder.
Silva E, Filipini R, Monteiro C, Valenti V, de Carvalho S, Wajnsztejn R Int Arch Med. 2013; 6(1):22.
PMID: 23656636 PMC: 3671139. DOI: 10.1186/1755-7682-6-22.