PDGFRA/NG2 Glia Generate Myelinating Oligodendrocytes and Piriform Projection Neurons in Adult Mice

Overview

Journal Nat Neurosci

Date 2008 Oct 14

PMID 18849983

Citations 506

Authors

Leanne E Rivers

Kaylene M Young

Matteo Rizzi

Francoise Jamen

Konstantina Psachoulia

Anna Wade

Nicoletta Kessaris

William D Richardson

Affiliations

Soon will be listed here.

Abstract

Platelet-derived growth factor alpha receptor (PDGFRA)/NG2-expressing glia are distributed throughout the adult CNS. They are descended from oligodendrocyte precursors (OLPs) in the perinatal CNS, but it is not clear whether they continue to generate myelinating oligodendrocytes or other differentiated cells during normal adult life. We followed the fates of adult OLPs in Pdgfra-creER(T2)/Rosa26-YFP double-transgenic mice and found that they generated many myelinating oligodendrocytes during adulthood; >20% of all oligodendrocytes in the adult mouse corpus callosum were generated after 7 weeks of age, raising questions about the function of the late-myelinating axons. OLPs also produced some myelinating cells in the cortex, but the majority of adult-born cortical cells did not appear to myelinate. We found no evidence for astrocyte production in gray or white matter. However, small numbers of projection neurons were generated in the forebrain, especially in the piriform cortex, which is the main target of the olfactory bulb.

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