Structure and Chemistry of the P300/CBP and Rtt109 Histone Acetyltransferases: Implications for Histone Acetyltransferase Evolution and Function

Overview

Journal Curr Opin Struct Biol

Date 2008 Oct 11

PMID 18845255

Citations 91

Authors

Ling Wang

Yong Tang

Philip A Cole

Ronen Marmorstein

Affiliations

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Abstract

The recent structure and associated biochemical studies of the metazoan-specific p300/CBP and fungal-specific Rtt109 histone acetyltransferases (HATs) have provided new insights into the ancestral relationship between HATs and their functions. These studies point to a common HAT ancester that has evolved around a common structural framework to form HATs with divergent catalytic and substrate-binding properties. These studies also point to the importance of regulatory loops within HATs and autoacetylation in HAT function. Implications for future studies are discussed.

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