Molecular Energy Dissipation in Nanoscale Networks of Dentin Matrix Protein 1 is Strongly Dependent on Ion Valence

Overview

Journal Nanotechnology

Specialty Biotechnology

Date 2008 Oct 10

PMID 18843380

Citations 11

Authors

J Adams

G E Fantner

L W Fisher

P K Hansma

Affiliations

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Abstract

The fracture resistance of biomineralized tissues such as bone, dentin, and abalone is greatly enhanced through the nanoscale interactions of stiff inorganic mineral components with soft organic adhesive components. A proper understanding of the interactions that occur within the organic component, and between the organic and inorganic components, is therefore critical for a complete understanding of the mechanics of these tissues. In this paper, we use Atomic Force Microscope (AFM) force spectroscopy and dynamic force spectroscopy to explore the effect of ionic interactions within a nanoscale system consisting of networks of Dentin Matrix Protein 1 (DMP1) (a component of both bone and dentin organic matrix), a mica surface, and an AFM tip. We find that DMP1 is capable of dissipating large amounts of energy through an ion-mediated mechanism, and that the effectiveness increases with increasing ion valence.

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References

Tai K, Ulm F, Ortiz C . Nanogranular origins of the strength of bone. Nano Lett. 2006; 6(11):2520-5. DOI: 10.1021/nl061877k. View

Sun C, Fantner G, Adams J, Hansma P, Waite J . The role of calcium and magnesium in the concrete tubes of the sandcastle worm. J Exp Biol. 2007; 210(Pt 8):1481-8. DOI: 10.1242/jeb.02759. View

Thompson J, Kindt J, Drake B, Hansma H, Morse D, Hansma P . Bone indentation recovery time correlates with bond reforming time. Nature. 2001; 414(6865):773-6. DOI: 10.1038/414773a. View

Prechtel K, Bausch A, Marchi-Artzner V, Kantlehner M, Kessler H, Merkel R . Dynamic force spectroscopy to probe adhesion strength of living cells. Phys Rev Lett. 2002; 89(2):028101. DOI: 10.1103/PhysRevLett.89.028101. View

Gupta H, Seto J, Wagermaier W, Zaslansky P, Boesecke P, Fratzl P . Cooperative deformation of mineral and collagen in bone at the nanoscale. Proc Natl Acad Sci U S A. 2006; 103(47):17741-6. PMC: 1635545. DOI: 10.1073/pnas.0604237103. View

Ogbureke K, Fisher L . SIBLING expression patterns in duct epithelia reflect the degree of metabolic activity. J Histochem Cytochem. 2007; 55(4):403-9. DOI: 10.1369/jhc.6A7075.2007. View

Janovjak H, Struckmeier J, Hubain M, Kedrov A, Kessler M, Muller D . Probing the energy landscape of the membrane protein bacteriorhodopsin. Structure. 2004; 12(5):871-9. DOI: 10.1016/j.str.2004.03.016. View

Kamat S, Su X, Ballarini R, Heuer A . Structural basis for the fracture toughness of the shell of the conch Strombus gigas. Nature. 2000; 405(6790):1036-40. DOI: 10.1038/35016535. View

He G, Dahl T, Veis A, George A . Nucleation of apatite crystals in vitro by self-assembled dentin matrix protein 1. Nat Mater. 2003; 2(8):552-8. DOI: 10.1038/nmat945. View

10.

Tartaix P, Doulaverakis M, George A, Fisher L, Butler W, Qin C . In vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insights into in vivo functions. J Biol Chem. 2004; 279(18):18115-20. DOI: 10.1074/jbc.M314114200. View

11.

George A, Sabsay B, Simonian P, Veis A . Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization. J Biol Chem. 1993; 268(17):12624-30. View

12.

Fantner G, Oroudjev E, Schitter G, Golde L, Thurner P, Finch M . Sacrificial bonds and hidden length: unraveling molecular mesostructures in tough materials. Biophys J. 2005; 90(4):1411-8. PMC: 1367291. DOI: 10.1529/biophysj.105.069344. View

13.

Goldsmith H, Labrosse J, McIntosh F, Maenpaa P, Kaartinen M, McKee M . Homotypic interactions of soluble and immobilized osteopontin. Ann Biomed Eng. 2002; 30(6):840-50. DOI: 10.1114/1.1497383. View

14.

Ling Y, Rios H, Myers E, Lu Y, Feng J, Boskey A . DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. J Bone Miner Res. 2005; 20(12):2169-77. PMC: 1456072. DOI: 10.1359/JBMR.050815. View

15.

George A, Silberstein R, Veis A . In situ hybridization shows Dmp1 (AG1) to be a developmentally regulated dentin-specific protein produced by mature odontoblasts. Connect Tissue Res. 1995; 33(1-3):67-72. DOI: 10.3109/03008209509016984. View

16.

Fantner G, Birkedal H, Kindt J, Hassenkam T, Weaver J, Cutroni J . Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone. Bone. 2004; 35(5):1013-22. DOI: 10.1016/j.bone.2004.05.027. View

17.

Fantner G, Hassenkam T, Kindt J, Weaver J, Birkedal H, Pechenik L . Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture. Nat Mater. 2005; 4(8):612-6. DOI: 10.1038/nmat1428. View

18.

Rief M, Gautel M, Oesterhelt F, Fernandez J, Gaub H . Reversible unfolding of individual titin immunoglobulin domains by AFM. Science. 1997; 276(5315):1109-12. DOI: 10.1126/science.276.5315.1109. View

19.

Narayanan K, Ramachandran A, Hao J, He G, Park K, Cho M . Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. J Biol Chem. 2003; 278(19):17500-8. DOI: 10.1074/jbc.M212700200. View

20.

Fisher L, Torchia D, Fohr B, Young M, Fedarko N . Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin. Biochem Biophys Res Commun. 2001; 280(2):460-5. DOI: 10.1006/bbrc.2000.4146. View