Reproducibility of Tumor Blood Flow Quantification with 15O-water PET

Overview

Journal J Nucl Med

Specialty Nuclear Medicine

Date 2008 Oct 4

PMID 18832120

Citations 14

Authors

Martin A Lodge

Heather A Jacene

Roberto Pili

Richard L Wahl

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Noninvasive methods for quantifying tumor blood flow (TBF) have a potentially important role in the field of drug development. (15)O-water PET has been used in several studies aimed at monitoring response to novel treatments. Assessing the significance of changes in TBF requires knowledge of the reproducibility of the technique. This article quantifies the reproducibility of the (15)O-water technique for TBF applications.

Methods: A total of 43 pairs of replicate (15)O-water studies were performed on 23 different patients with cancer. TBF was estimated using a standard, single-compartment model, and the replicate data were used to assess the reproducibility of the method.

Results: The magnitude of the differences between replicate flow measurements was found to be proportional to their means. TBF was measured with a within-subject coefficient of variation of 13.4% and a repeatability of 37.1%. The volume of distribution was measured with a within-subject coefficient of variation of 8.6% and a repeatability of 24.0%.

Conclusion: (15)O-water PET can be used to measure TBF with a reproducibility that is consistent with other applications of the technique. The short half-life of the isotope permits multiple replicate studies to be performed during the same imaging session, allowing the reproducibility of the average flow estimate to be adapted to the required task. (15)O-water PET is a powerful and robust tool for TBF quantification.

Citing Articles

Compartmental modeling for blood flow quantification from dynamic O-water PET images of humans: a systematic review.

Rainio O, Klen R Ann Nucl Med. 2025; 39(3):231-246.

PMID: 39832118 PMC: 11829939. DOI: 10.1007/s12149-025-02014-x.

Repeatability of [O]HO PET imaging for lower extremity skeletal muscle perfusion: a test-retest study.

Christensen N, Sorensen J, Bouchelouche K, Madsen M, Buhl C, Tolbod L EJNMMI Res. 2024; 14(1):11.

PMID: 38294730 PMC: 10830956. DOI: 10.1186/s13550-024-01073-x.

Molecular and functional imaging in cancer-targeted therapy: current applications and future directions.

Bai J, Qiu S, Zhang G Signal Transduct Target Ther. 2023; 8(1):89.

PMID: 36849435 PMC: 9971190. DOI: 10.1038/s41392-023-01366-y.

Whole-Body Parametric Imaging of F-FDG PET Using uEXPLORER with Reduced Scanning Time.

Wu Y, Feng T, Zhao Y, Xu T, Fu F, Huang Z J Nucl Med. 2021; 63(4):622-628.

PMID: 34385335 PMC: 8973287. DOI: 10.2967/jnumed.120.261651.

Patient-Specific Characterization of Breast Cancer Hemodynamics Using Image-Guided Computational Fluid Dynamics.

Wu C, Hormuth D, Oliver T, Pineda F, Lorenzo G, Karczmar G IEEE Trans Med Imaging. 2020; 39(9):2760-2771.

PMID: 32086203 PMC: 7438313. DOI: 10.1109/TMI.2020.2975375.

References

Burger C, Goerres G, Schoenes S, Buck A, Lonn A, von Schulthess G . PET attenuation coefficients from CT images: experimental evaluation of the transformation of CT into PET 511-keV attenuation coefficients. Eur J Nucl Med Mol Imaging. 2002; 29(7):922-7. DOI: 10.1007/s00259-002-0796-3. View

Mankoff D, Dunnwald L, Gralow J, Ellis G, Charlop A, Lawton T . Blood flow and metabolism in locally advanced breast cancer: relationship to response to therapy. J Nucl Med. 2002; 43(4):500-9. View

Uren N, Camici P, Melin J, Bol A, de Bruyne B, Radvan J . Effect of aging on myocardial perfusion reserve. J Nucl Med. 1995; 36(11):2032-6. View

DeGrado T, Turkington T, Williams J, Stearns C, Hoffman J, Coleman R . Performance characteristics of a whole-body PET scanner. J Nucl Med. 1994; 35(8):1398-406. View

Saleem A, Yap J, Osman S, Brady F, Suttle B, Lucas S . Modulation of fluorouracil tissue pharmacokinetics by eniluracil: in-vivo imaging of drug action. Lancet. 2000; 355(9221):2125-31. DOI: 10.1016/s0140-6736(00)02380-1. View

Wilson C, Lammertsma A, MCKENZIE C, Sikora K, Jones T . Measurements of blood flow and exchanging water space in breast tumors using positron emission tomography: a rapid and noninvasive dynamic method. Cancer Res. 1992; 52(6):1592-7. View

Lammertsma A, Wise R, Heather J, Gibbs J, Leenders K, Frackowiak R . Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 2. Results in normal subjects and brain tumour and stroke patients. J Cereb Blood Flow Metab. 1983; 3(4):425-31. DOI: 10.1038/jcbfm.1983.68. View

Tseng J, Dunnwald L, Schubert E, Link J, Minoshima S, Muzi M . 18F-FDG kinetics in locally advanced breast cancer: correlation with tumor blood flow and changes in response to neoadjuvant chemotherapy. J Nucl Med. 2004; 45(11):1829-37. View

Muramoto S, Uematsu H, Sadato N, Tsuchida T, Matsuda T, Hatabu H . H(2) (15)0 positron emission tomography validation of semiquantitative prostate blood flow determined by double-echo dynamic MRI: a preliminary study. J Comput Assist Tomogr. 2002; 26(4):510-4. DOI: 10.1097/00004728-200207000-00005. View

10.

Tomura N, Kato T, Kanno I, Shishido F, Inugami A, Uemura K . Increased blood flow in human brain tumor after administration of angiotensin II: demonstration by PET. Comput Med Imaging Graph. 1993; 17(6):443-9. DOI: 10.1016/0895-6111(93)90060-z. View

11.

Hoekstra C, Stroobants S, Hoekstra O, Smit E, Vansteenkiste J, Lammertsma A . Measurement of perfusion in stage IIIA-N2 non-small cell lung cancer using H(2)(15)O and positron emission tomography. Clin Cancer Res. 2002; 8(7):2109-15. View

12.

Ponto L, Madsen M, Hichwa R, Mayr N, Yuh W, Magnotta V . Assessment of Blood Flow in Solid Tumors Using PET. Clin Positron Imaging. 2003; 1(2):117-121. DOI: 10.1016/s1095-0397(98)00006-5. View

13.

Lehtio K, Eskola O, Viljanen T, Oikonen V, Gronroos T, Sillanmaki L . Imaging perfusion and hypoxia with PET to predict radiotherapy response in head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2004; 59(4):971-82. DOI: 10.1016/j.ijrobp.2003.12.014. View

14.

Kaufmann P, Gnecchi-Ruscone T, Yap J, Rimoldi O, Camici P . Assessment of the reproducibility of baseline and hyperemic myocardial blood flow measurements with 15O-labeled water and PET. J Nucl Med. 1999; 40(11):1848-56. View

15.

Koh T, Taniguchi H, Yamagishi H . Oxygen-15 positron-emission tomography for predicting selective delivery of a chemotherapeutic agent to hepatic cancers during angiotensin II-induced hypertension. Cancer Chemother Pharmacol. 2003; 51(4):349-58. DOI: 10.1007/s00280-003-0575-2. View

16.

Kubo S, Yamamoto K, Magata Y, Iwasaki Y, Tamaki N, Yonekura Y . Assessment of pancreatic blood flow with positron emission tomography and oxygen-15 water. Ann Nucl Med. 1991; 5(4):133-8. DOI: 10.1007/BF03164627. View

17.

Bland J, Altman D . Measuring agreement in method comparison studies. Stat Methods Med Res. 1999; 8(2):135-60. DOI: 10.1177/096228029900800204. View

18.

Anderson H, Yap J, Miller M, Robbins A, Jones T, Price P . Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate. J Clin Oncol. 2003; 21(15):2823-30. DOI: 10.1200/JCO.2003.05.186. View

19.

Ito M, Lammertsma A, Wise R, Bernardi S, Frackowiak R, Heather J . Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using 15O and positron emission tomography: analytical techniques and preliminary results. Neuroradiology. 1982; 23(2):63-74. DOI: 10.1007/BF00367239. View

20.

Gupta N, Saleem A, Kotz B, Osman S, Aboagye E, Phillips R . Carbogen and nicotinamide increase blood flow and 5-fluorouracil delivery but not 5-fluorouracil retention in colorectal cancer metastases in patients. Clin Cancer Res. 2006; 12(10):3115-23. DOI: 10.1158/1078-0432.CCR-05-0513. View