Inositol Metabolism in Yeasts

Because of its accessibility to genetic and molecular studies, Sacch. cerevisiae is an attractive organism in which to pursue studies of the complex roles of phosphoinositides and other inositol-containing metabolites. Biochemical studies have clearly demonstrated that PI, PIP, PIP2 and the inositol phosphates derived from them exist in Sacch. cerevisiae. It is clear that they are synthesized and turned over following pathways similar to those described in higher eukaryotes. Recent studies on yeast have also suggested that inositol phospholipids may play roles in complex signalling pathways similar to those detected in animal cells. In addition, inositol has been demonstrated to function in yeast as a global regulator of phospholipid synthesis. This regulation occurs on a transcriptional level and is highly complex. It is not yet known whether similar inositol-mediated regulation of phospholipid synthesis occurs in other eukaryotes.