A Multivariate Analysis of Serum Nutrient Levels and Lung Function

Overview

Journal Respir Res

Specialty Pulmonary Medicine

Date 2008 Oct 1

PMID 18823528

Citations 49

Authors

Tricia M McKeever

Sarah A Lewis

Henriette A Smit

Peter Burney

Patricia A Cassano

John Britton

Affiliations

Soon will be listed here.

Abstract

Background: There is mounting evidence that estimates of intakes of a range of dietary nutrients are related to both lung function level and rate of decline, but far less evidence on the relation between lung function and objective measures of serum levels of individual nutrients. The aim of this study was to conduct a comprehensive examination of the independent associations of a wide range of serum markers of nutritional status with lung function, measured as the one-second forced expiratory volume (FEV1).

Methods: Using data from the Third National Health and Nutrition Examination Survey, a US population-based cross-sectional study, we investigated the relation between 21 serum markers of potentially relevant nutrients and FEV1, with adjustment for potential confounding factors. Systematic approaches were used to guide the analysis.

Results: In a mutually adjusted model, higher serum levels of antioxidant vitamins (vitamin A, beta-cryptoxanthin, vitamin C, vitamin E), selenium, normalized calcium, chloride, and iron were independently associated with higher levels of FEV1. Higher concentrations of potassium and sodium were associated with lower FEV1.

Conclusion: Maintaining higher serum concentrations of dietary antioxidant vitamins and selenium is potentially beneficial to lung health. In addition other novel associations found in this study merit further investigation.

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References

Piatti G, Allegra L, Ambrosetti U, Cappellini M, Turati F, Fiorelli G . Beta-thalassemia and pulmonary function. Haematologica. 1999; 84(9):804-8. View

Tong G, Rude R . Magnesium deficiency in critical illness. J Intensive Care Med. 2005; 20(1):3-17. DOI: 10.1177/0885066604271539. View

Pearson P, Britton J, McKeever T, Lewis S, Weiss S, Pavord I . Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population. Eur J Clin Nutr. 2005; 59(9):1043-8. DOI: 10.1038/sj.ejcn.1602209. View

Patel B, Welch A, Bingham S, Luben R, Day N, Khaw K . Dietary antioxidants and asthma in adults. Thorax. 2006; 61(5):388-93. PMC: 2111195. DOI: 10.1136/thx.2004.024935. View

Schunemann H, Grant B, Freudenheim J, Muti P, Browne R, Drake J . The relation of serum levels of antioxidant vitamins C and E, retinol and carotenoids with pulmonary function in the general population. Am J Respir Crit Care Med. 2001; 163(5):1246-55. DOI: 10.1164/ajrccm.163.5.2007135. View

Kassaye T, BECKLAKE M, Receveur O, Hanley J, Johns T . Association between vitamin A status and lung function level in children aged 6--9 years in Wukro wereda, Northern Ethiopia. Int J Epidemiol. 2001; 30(3):457-64. DOI: 10.1093/ije/30.3.457. View

Alamoudi O . Electrolyte disturbances in patients with chronic, stable asthma: effect of therapy. Chest. 2001; 120(2):431-6. DOI: 10.1378/chest.120.2.431. View

. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002; 360(9326):23-33. DOI: 10.1016/S0140-6736(02)09328-5. View

Schunemann H, Freudenheim J, Grant B . Epidemiologic evidence linking antioxidant vitamins to pulmonary function and airway obstruction. Epidemiol Rev. 2002; 23(2):248-67. DOI: 10.1093/oxfordjournals.epirev.a000805. View

10.

Romieu I, Trenga C . Diet and obstructive lung diseases. Epidemiol Rev. 2002; 23(2):268-87. DOI: 10.1093/oxfordjournals.epirev.a000806. View

11.

Li A, Chan D, Li C, Wong E, Chan Y, Fok T . Respiratory function in patients with thalassaemia major: relation with iron overload. Arch Dis Child. 2002; 87(4):328-30. PMC: 1763020. DOI: 10.1136/adc.87.4.328. View

12.

Kelly Y, Sacker A, Marmot M . Nutrition and respiratory health in adults: findings from the health survey for Scotland. Eur Respir J. 2003; 21(4):664-71. DOI: 10.1183/09031936.03.00055702. View

13.

Carnelli V, DAngelo E, Pecchiari M, Ligorio M, DAngelo E . Pulmonary dysfunction in transfusion-dependent patients with thalassemia major. Am J Respir Crit Care Med. 2003; 168(2):180-4. DOI: 10.1164/rccm.200211-1292OC. View

14.

Rubin R, Navon L, Cassano P . Relationship of serum antioxidants to asthma prevalence in youth. Am J Respir Crit Care Med. 2003; 169(3):393-8. DOI: 10.1164/rccm.200301-055OC. View

15.

McKeever T, Britton J . Diet and asthma. Am J Respir Crit Care Med. 2004; 170(7):725-9. DOI: 10.1164/rccm.200405-611PP. View

16.

Packer J, Slater T, Willson R . Direct observation of a free radical interaction between vitamin E and vitamin C. Nature. 1979; 278(5706):737-8. DOI: 10.1038/278737a0. View

17.

Burney P, Britton J, Chinn S, Tattersfield A, PLATT H, Papacosta A . Response to inhaled histamine and 24 hour sodium excretion. Br Med J (Clin Res Ed). 1986; 292(6534):1483-6. PMC: 1340493. DOI: 10.1136/bmj.292.6534.1483. View

18.

Burney P, Neild J, Twort C, Chinn S, Jones T, Mitchell W . Effect of changing dietary sodium on the airway response to histamine. Thorax. 1989; 44(1):36-41. PMC: 461661. DOI: 10.1136/thx.44.1.36. View

19.

Flatt A, Pearce N, Thomson C, Sears M, Robinson M, Beasley R . Reduced selenium in asthmatic subjects in New Zealand. Thorax. 1990; 45(2):95-9. PMC: 462313. DOI: 10.1136/thx.45.2.95. View

20.

Grievink L, Smit H, van t Veer P, Brunekreef B, Kromhout D . A case-control study of plasma antioxidant (pro-)vitamins in relation to respiratory symptoms in non-smokers. Epidemiology. 2000; 11(1):59-63. DOI: 10.1097/00001648-200001000-00013. View